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@article{1420081,
author = {Opatrilova, Radka and Caprnda, Martin and Kubatka, Peter and Valentova, Vanda and Uramova, Sona and Nosal, Vladimir and Gaspar, Ludovit and Zachar, Lukas and Mozos, Ioana and Petrovic, Daniel and Dragasek, Jozef and Filipova, Slavomira and Busselberg, Dietrich and Zulli, Anthony and Rodrigo, Luis and Kružliak, Peter and Krasnik, Vladimir},
article_location = {PARIS},
article_number = {FEB 2018},
doi = {http://dx.doi.org/10.1016/j.biopha.2017.12.074},
keywords = {Adipokines; Leptin; Adiponectin; Resistin; Apelin; Visfatin; Atherosclerosis; Ischemic stroke; Metabolic changes; Inflammation},
language = {eng},
issn = {0753-3322},
journal = {BIOMEDICINE & PHARMACOTHERAPY},
title = {Adipokines in neurovascular diseases},
volume = {98},
year = {2018}
}
TY - JOUR
ID - 1420081
AU - Opatrilova, Radka - Caprnda, Martin - Kubatka, Peter - Valentova, Vanda - Uramova, Sona - Nosal, Vladimir - Gaspar, Ludovit - Zachar, Lukas - Mozos, Ioana - Petrovic, Daniel - Dragasek, Jozef - Filipova, Slavomira - Busselberg, Dietrich - Zulli, Anthony - Rodrigo, Luis - Kružliak, Peter - Krasnik, Vladimir
PY - 2018
TI - Adipokines in neurovascular diseases
JF - BIOMEDICINE & PHARMACOTHERAPY
VL - 98
IS - FEB 2018
SP - 424-432
EP - 424-432
PB - ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
SN - 07533322
KW - Adipokines
KW - Leptin
KW - Adiponectin
KW - Resistin
KW - Apelin
KW - Visfatin
KW - Atherosclerosis
KW - Ischemic stroke
KW - Metabolic changes
KW - Inflammation
N2 - Adipose tissue is now described as an endocrine organ secreting a number of adipokines contributing to the development of inflammation and metabolic imbalance, but also endothelial dysfunction, vascular remodeling, atherosclerosis, and ischemic stroke. Leptin, adiponectin, and resistin are the most studied adipokines which play important roles in the regulation of cardiovascular homeostasis. Leptin and adiponectin mediate both proatherogenic and antiatherogenic responses. Leptin and adiponectin have been linked to the development of coronary heart disease and may be involved in the underlying biological mechanism of ischemic stroke. Resistin, a pro-inflammatory cytokine, is predictive of atherosclerosis and poor clinical outcomes in patients with coronary artery disease and ischemic stroke. The changes in serum levels of novel adipokines apelin, visfatin are also associated with acute ischemic stroke. These adipokines have been proposed as potential prognostic biomarkers of cardiovascular mortality/morbidity and therapeutic targets in patients with cardiometabolic diseases. In this article, we summarize the biologic role of the adipokines and discuss the link between dysfunctional adipose tissue and metabolic/inflammation imbalance, consequently endothelial damage, progression of atherosclerotic disease, and the occurrence of ischemic stroke.
ER -
OPATRILOVA, Radka, Martin CAPRNDA, Peter KUBATKA, Vanda VALENTOVA, Sona URAMOVA, Vladimir NOSAL, Ludovit GASPAR, Lukas ZACHAR, Ioana MOZOS, Daniel PETROVIC, Jozef DRAGASEK, Slavomira FILIPOVA, Dietrich BUSSELBERG, Anthony ZULLI, Luis RODRIGO, Peter KRUŽLIAK a Vladimir KRASNIK. Adipokines in neurovascular diseases. \textit{BIOMEDICINE \&{}amp; PHARMACOTHERAPY}. PARIS: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, roč.~98, FEB 2018, s.~424-432. ISSN~0753-3322. doi:10.1016/j.biopha.2017.12.074. 2018.
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