Adipokines in neurovascular diseases

J 2018

Adipokines in neurovascular diseases

OPATRILOVA, Radka, Martin CAPRNDA, Peter KUBATKA, Vanda VALENTOVA, Sona URAMOVA et. al.

Basic information

Original name

Adipokines in neurovascular diseases

Authors

OPATRILOVA, Radka (203 Czech Republic), Martin CAPRNDA (703 Slovakia), Peter KUBATKA (703 Slovakia), Vanda VALENTOVA (703 Slovakia), Sona URAMOVA (703 Slovakia), Vladimir NOSAL (703 Slovakia), Ludovit GASPAR (703 Slovakia), Lukas ZACHAR (703 Slovakia), Ioana MOZOS (642 Romania), Daniel PETROVIC (705 Slovenia), Jozef DRAGASEK (703 Slovakia), Slavomira FILIPOVA (703 Slovakia), Dietrich BUSSELBERG (634 Qatar), Anthony ZULLI (36 Australia), Luis RODRIGO (724 Spain), Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution) and Vladimir KRASNIK (703 Slovakia)

Edition

BIOMEDICINE & PHARMACOTHERAPY, PARIS, ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2018, 0753-3322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

France

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.743

RIV identification code

RIV/00216224:14110/18:00102964

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.biopha.2017.12.074

UT WoS

000426104000053

Keywords in English

Adipokines; Leptin; Adiponectin; Resistin; Apelin; Visfatin; Atherosclerosis; Ischemic stroke; Metabolic changes; Inflammation

Abstract

V originále

Adipose tissue is now described as an endocrine organ secreting a number of adipokines contributing to the development of inflammation and metabolic imbalance, but also endothelial dysfunction, vascular remodeling, atherosclerosis, and ischemic stroke. Leptin, adiponectin, and resistin are the most studied adipokines which play important roles in the regulation of cardiovascular homeostasis. Leptin and adiponectin mediate both proatherogenic and antiatherogenic responses. Leptin and adiponectin have been linked to the development of coronary heart disease and may be involved in the underlying biological mechanism of ischemic stroke. Resistin, a pro-inflammatory cytokine, is predictive of atherosclerosis and poor clinical outcomes in patients with coronary artery disease and ischemic stroke. The changes in serum levels of novel adipokines apelin, visfatin are also associated with acute ischemic stroke. These adipokines have been proposed as potential prognostic biomarkers of cardiovascular mortality/morbidity and therapeutic targets in patients with cardiometabolic diseases. In this article, we summarize the biologic role of the adipokines and discuss the link between dysfunctional adipose tissue and metabolic/inflammation imbalance, consequently endothelial damage, progression of atherosclerotic disease, and the occurrence of ischemic stroke.

Citovat

OPATRILOVA, Radka, Martin CAPRNDA, Peter KUBATKA, Vanda VALENTOVA, Sona URAMOVA, Vladimir NOSAL, Ludovit GASPAR, Lukas ZACHAR, Ioana MOZOS, Daniel PETROVIC, Jozef DRAGASEK, Slavomira FILIPOVA, Dietrich BUSSELBERG, Anthony ZULLI, Luis RODRIGO, Peter KRUŽLIAK and Vladimir KRASNIK. Adipokines in neurovascular diseases. BIOMEDICINE & PHARMACOTHERAPY. PARIS: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2018, vol. 98, FEB 2018, p. 424-432. ISSN 0753-3322. Available from: https://dx.doi.org/10.1016/j.biopha.2017.12.074.

@article{1420081,
   author = {Opatrilova, Radka and Caprnda, Martin and Kubatka, Peter and Valentova, Vanda and Uramova, Sona and Nosal, Vladimir and Gaspar, Ludovit and Zachar, Lukas and Mozos, Ioana and Petrovic, Daniel and Dragasek, Jozef and Filipova, Slavomira and Busselberg, Dietrich and Zulli, Anthony and Rodrigo, Luis and Kružliak, Peter and Krasnik, Vladimir},
   article_location = {PARIS},
   article_number = {FEB 2018},
   doi = {http://dx.doi.org/10.1016/j.biopha.2017.12.074},
   keywords = {Adipokines; Leptin; Adiponectin; Resistin; Apelin; Visfatin; Atherosclerosis; Ischemic stroke; Metabolic changes; Inflammation},
   language = {eng},
   issn = {0753-3322},
   journal = {BIOMEDICINE & PHARMACOTHERAPY},
   title = {Adipokines in neurovascular diseases},
   volume = {98},
   year = {2018}
}

TY  - JOUR
ID  - 1420081
AU  - Opatrilova, Radka - Caprnda, Martin - Kubatka, Peter - Valentova, Vanda - Uramova, Sona - Nosal, Vladimir - Gaspar, Ludovit - Zachar, Lukas - Mozos, Ioana - Petrovic, Daniel - Dragasek, Jozef - Filipova, Slavomira - Busselberg, Dietrich - Zulli, Anthony - Rodrigo, Luis - Kružliak, Peter - Krasnik, Vladimir
PY  - 2018
TI  - Adipokines in neurovascular diseases
JF  - BIOMEDICINE & PHARMACOTHERAPY
VL  - 98
IS  - FEB 2018
SP  - 424-432
EP  - 424-432
PB  - ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
SN  - 07533322
KW  - Adipokines
KW  - Leptin
KW  - Adiponectin
KW  - Resistin
KW  - Apelin
KW  - Visfatin
KW  - Atherosclerosis
KW  - Ischemic stroke
KW  - Metabolic changes
KW  - Inflammation
N2  - Adipose tissue is now described as an endocrine organ secreting a number of adipokines contributing to the development of inflammation and metabolic imbalance, but also endothelial dysfunction, vascular remodeling, atherosclerosis, and ischemic stroke. Leptin, adiponectin, and resistin are the most studied adipokines which play important roles in the regulation of cardiovascular homeostasis. Leptin and adiponectin mediate both proatherogenic and antiatherogenic responses. Leptin and adiponectin have been linked to the development of coronary heart disease and may be involved in the underlying biological mechanism of ischemic stroke. Resistin, a pro-inflammatory cytokine, is predictive of atherosclerosis and poor clinical outcomes in patients with coronary artery disease and ischemic stroke. The changes in serum levels of novel adipokines apelin, visfatin are also associated with acute ischemic stroke. These adipokines have been proposed as potential prognostic biomarkers of cardiovascular mortality/morbidity and therapeutic targets in patients with cardiometabolic diseases. In this article, we summarize the biologic role of the adipokines and discuss the link between dysfunctional adipose tissue and metabolic/inflammation imbalance, consequently endothelial damage, progression of atherosclerotic disease, and the occurrence of ischemic stroke.
ER  -

OPATRILOVA, Radka, Martin CAPRNDA, Peter KUBATKA, Vanda VALENTOVA, Sona URAMOVA, Vladimir NOSAL, Ludovit GASPAR, Lukas ZACHAR, Ioana MOZOS, Daniel PETROVIC, Jozef DRAGASEK, Slavomira FILIPOVA, Dietrich BUSSELBERG, Anthony ZULLI, Luis RODRIGO, Peter KRUŽLIAK and Vladimir KRASNIK. Adipokines in neurovascular diseases. \textit{BIOMEDICINE \&{}amp; PHARMACOTHERAPY}. PARIS: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2018, vol.~98, FEB 2018, p.~424-432. ISSN~0753-3322. Available from: https://dx.doi.org/10.1016/j.biopha.2017.12.074.

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