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@article{1423285,
author = {Vítovec, Jiří and Špinar, Jindřich and Špinarová, Lenka},
article_location = {Amsterdam},
article_number = {3},
doi = {http://dx.doi.org/10.1016/j.crvasa.2018.02.003},
keywords = {Chronic heart failure; ACE inhibitors; Angiotensin receptor blockers; Mineralocorticoid receptor; antagonists; Aliskiren; Omapatrilat; Sacubitril/valsartan (LCZ 696)},
language = {eng},
issn = {0010-8650},
journal = {Cor et Vasa},
title = {Heart failure and inhibition of renin-angiotensin-aldosterone system},
volume = {60},
year = {2018}
}
TY - JOUR
ID - 1423285
AU - Vítovec, Jiří - Špinar, Jindřich - Špinarová, Lenka
PY - 2018
TI - Heart failure and inhibition of renin-angiotensin-aldosterone system
JF - Cor et Vasa
VL - 60
IS - 3
SP - "E263"-"E273"
EP - "E263"-"E273"
PB - Elsevier Science INC
SN - 00108650
KW - Chronic heart failure
KW - ACE inhibitors
KW - Angiotensin receptor blockers
KW - Mineralocorticoid receptor
KW - antagonists
KW - Aliskiren
KW - Omapatrilat
KW - Sacubitril/valsartan (LCZ 696)
N2 - A historical survey is presented of mortality clinical trials focussed on the inhibition of the renin-angiotensin-aldosterone system on different levels in patients with chronic heart failure. The first study, CONSENSUS, was published in 1987 and showed that the ACE-inhibitor enalapril clearly reduced mortality in severe heart failure compared with placebo. This was followed by studies with beta blockers, angiotensin II type 1 receptor blockers, blockers of mineralocorticoid receptors, and direct renin inhibitors. A recent study, PARADIGM, comparing dual inhibitor of neprilysin and antiotensin II receptor (LCZ 696) with enalapril, was terminated prematurely for a significant effect of inhibiting neprilysin and valsartan. (C) 2018 The Czech Society of Cardiology. Published by Elsevier Sp. z o.o. All rights reserved.
ER -
VÍTOVEC, Jiří, Jindřich ŠPINAR a Lenka ŠPINAROVÁ. Heart failure and inhibition of renin-angiotensin-aldosterone system. \textit{Cor et Vasa}. Amsterdam: Elsevier Science INC, roč.~60, č.~3, s.~''E263''-''E273'', 11 s. ISSN~0010-8650. doi:10.1016/j.crvasa.2018.02.003. 2018.
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