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@article{1423307,
author = {Brat, Kristián and Plutinský, Marek and Hejduk, Karel and Svoboda, Michal and Popelkova, Patrice and Zatloukal, Jaromir and Volakova, Eva and Pecaninova, Miroslava and Heribanova, Lucie and Koblizek, Vladimir},
article_location = {Auckland},
article_number = {2018},
doi = {http://dx.doi.org/10.2147/COPD.S147262},
keywords = {COPD; GOLD 2017 update; Hypercapnia; Hypoxemia; Mortality},
language = {eng},
issn = {1178-2005},
journal = {INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE},
title = {Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B},
volume = {13},
year = {2018}
}
TY - JOUR
ID - 1423307
AU - Brat, Kristián - Plutinský, Marek - Hejduk, Karel - Svoboda, Michal - Popelkova, Patrice - Zatloukal, Jaromir - Volakova, Eva - Pecaninova, Miroslava - Heribanova, Lucie - Koblizek, Vladimir
PY - 2018
TI - Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B
JF - INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
VL - 13
IS - 2018
SP - 1037-1052
EP - 1037-1052
PB - Dove Medical Press Ltd.
SN - 11782005
KW - COPD
KW - GOLD 2017 update
KW - Hypercapnia
KW - Hypoxemia
KW - Mortality
N2 - Background: Respiratory parameters are important predictors of prognosis in the COPD population. Global Initiative for Obstructive Lung Disease (GOLD) 2017 Update resulted in a vertical shift of patients across COPD categories, with category B being the most populous and clinically heterogeneous. The aim of our study was to investigate whether respiratory parameters might be associated with increased all-cause mortality within GOLD category B patients. Methods: The data were extracted from the Czech Multicentre Research Database, a prospective, noninterventional multicenter study of COPD patients. Kaplan–Meier survival analyses were performed at different levels of respiratory parameters (partial pressure of oxygen in arterial blood [PaO2], partial pressure of arterial carbon dioxide [PaCO2] and greatest decrease of basal peripheral capillary oxygen saturation during 6-minute walking test [6-MWT]). Univariate analyses using the Cox proportional hazard model and multivariate analyses were used to identify risk factors for mortality in hypoxemic and hypercapnic individuals with COPD. Results: All-cause mortality in the cohort at 3 years of prospective follow-up reached 18.4%. Chronic hypoxemia (PaO2<7.3 kPa), hypercapnia (PaCO2>7.0 kPa) and oxygen desaturation during the 6-MWT were predictors of long-term mortality in COPD patients with forced expiratory volume in 1 second #60% for the overall cohort and for GOLD B category patients. Univariate analyses confirmed the association among decreased oxemia (<7.3 kPa), increased capnemia (>7.0 kPa), oxygen desaturation during 6-MWT and mortality in the studied groups of COPD subjects. Multivariate analysis identified PaO2<7.3 kPa as a strong independent risk factor for mortality. Conclusion: Survival analyses showed significantly increased all-cause mortality in hypoxemic and hypercapnic GOLD B subjects. More important, PaO2<7.3 kPa was the strongest risk factor, especially in category B patients. In contrast, the majority of the tested respiratory parameters did not show a difference in mortality in the GOLD category D cohort.
ER -
BRAT, Kristián, Marek PLUTINSKÝ, Karel HEJDUK, Michal SVOBODA, Patrice POPELKOVA, Jaromir ZATLOUKAL, Eva VOLAKOVA, Miroslava PECANINOVA, Lucie HERIBANOVA a Vladimir KOBLIZEK. Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B. \textit{INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE}. Auckland: Dove Medical Press Ltd., 2018, roč.~13, č.~2018, s.~1037-1052. ISSN~1178-2005. Dostupné z: https://dx.doi.org/10.2147/COPD.S147262.
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