Association between genetic variability of neuronal nitric
oxide synthase and sensorimotor gating in humans

J 2018

Association between genetic variability of neuronal nitric oxide synthase and sensorimotor gating in humans

ROVNY, Rastislav, Martin MARKO, Stanislav KATINA, Jana MURINOVA, Veronika ROHARIKOVA et. al.

Basic information

Original name

Association between genetic variability of neuronal nitric oxide synthase and sensorimotor gating in humans

Authors

ROVNY, Rastislav (703 Slovakia), Martin MARKO (703 Slovakia), Stanislav KATINA (703 Slovakia, belonging to the institution), Jana MURINOVA (703 Slovakia), Veronika ROHARIKOVA (703 Slovakia), Barbora CIMROVA (703 Slovakia), Gabriela REPISKA (703 Slovakia), Gabriel MINARIK (703 Slovakia) and Igor RIECANSKY (703 Slovakia, guarantor)

Edition

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, Rochester, USA, Elsevier, 2018, 1089-8603

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10103 Statistics and probability

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.371

RIV identification code

RIV/00216224:14310/18:00103407

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.niox.2018.08.002

UT WoS

000448231800004

Keywords in English

Nitric oxide; NOS1; Schizophrenia; Prepulse inhibition; Startle; Endophenotypes

Abstract

V originále

Research increasingly suggests that nitric oxide (NO) plays a role in the pathogenesis of schizophrenia. One important line of evidence comes from genetic studies, which have repeatedly detected an association between the neuronal isoform of nitric oxide synthase (nNOS or NOS1) and schizophrenia. However, the pathogenetic pathways linking nNOS, NO, and the disorder remain poorly understood. A deficit in sensorimotor gating is considered to importantly contribute to core schizophrenia symptoms such as psychotic disorganization and thought disturbance. We selected three candidate nNOS polymorphisms (Ex1f-VNTR, rs6490121 and rs41279104), associated with schizophrenia and cognition in previous studies, and tested their association with the efficiency of sensorimotor gating in healthy human adults. We found that risk variants of Ex1f-VNTR and rs6490121 (but not rs41279104) were associated with a weaker prepulse inhibition (PPI) of the acoustic startle reflex, a standard measure of sensorimotor gating. Furthermore, the effect of presence of risk variants in Ex1f- VNTR and rs6490121 was additive: PPI linearly decreased with increasing number of risk alleles, being highest in participants with no risk allele, while lowest in individuals who carry three risk alleles. Our findings indicate that NO is involved in the regulation of sensorimotor gating, and highlight one possible pathogenetic mechanism for NO playing a role in the development of schizophrenia psychosis.

Citovat

ROVNY, Rastislav, Martin MARKO, Stanislav KATINA, Jana MURINOVA, Veronika ROHARIKOVA, Barbora CIMROVA, Gabriela REPISKA, Gabriel MINARIK and Igor RIECANSKY. Association between genetic variability of neuronal nitric oxide synthase and sensorimotor gating in humans. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. Rochester, USA: Elsevier, 2018, vol. 80, No 1, p. 32-36. ISSN 1089-8603. Available from: https://dx.doi.org/10.1016/j.niox.2018.08.002.

@article{1427216,
   author = {Rovny, Rastislav and Marko, Martin and Katina, Stanislav and Murinova, Jana and Roharikova, Veronika and Cimrova, Barbora and Repiska, Gabriela and Minarik, Gabriel and Riecansky, Igor},
   article_location = {Rochester, USA},
   article_number = {1},
   doi = {http://dx.doi.org/10.1016/j.niox.2018.08.002},
   keywords = {Nitric oxide; NOS1; Schizophrenia; Prepulse inhibition; Startle; Endophenotypes},
   language = {eng},
   issn = {1089-8603},
   journal = {NITRIC OXIDE-BIOLOGY AND CHEMISTRY},
   title = {Association between genetic variability of neuronal nitric oxide synthase and sensorimotor gating in humans},
   url = {https://www.sciencedirect.com/science/article/pii/S1089860318300260},
   volume = {80},
   year = {2018}
}

TY  - JOUR
ID  - 1427216
AU  - Rovny, Rastislav - Marko, Martin - Katina, Stanislav - Murinova, Jana - Roharikova, Veronika - Cimrova, Barbora - Repiska, Gabriela - Minarik, Gabriel - Riecansky, Igor
PY  - 2018
TI  - Association between genetic variability of neuronal nitric oxide synthase and sensorimotor gating in humans
JF  - NITRIC OXIDE-BIOLOGY AND CHEMISTRY
VL  - 80
IS  - 1
SP  - 32-36
EP  - 32-36
PB  - Elsevier
SN  - 10898603
KW  - Nitric oxide
KW  - NOS1
KW  - Schizophrenia
KW  - Prepulse inhibition
KW  - Startle
KW  - Endophenotypes
UR  - https://www.sciencedirect.com/science/article/pii/S1089860318300260
L2  - https://www.sciencedirect.com/science/article/pii/S1089860318300260
N2  - Research increasingly suggests that nitric oxide (NO) plays a role in the pathogenesis of schizophrenia. One important line of evidence comes from genetic studies, which have repeatedly detected an association between the neuronal isoform of nitric oxide synthase (nNOS or NOS1) and schizophrenia. However, the pathogenetic pathways linking nNOS, NO, and the disorder remain poorly understood. A deficit in sensorimotor gating is considered to importantly contribute to core schizophrenia symptoms such as psychotic disorganization and thought disturbance. We selected three candidate nNOS polymorphisms (Ex1f-VNTR, rs6490121 and rs41279104), associated with schizophrenia and cognition in previous studies, and tested their association with the efficiency of sensorimotor gating in healthy human adults. We found that risk variants of Ex1f-VNTR and rs6490121 (but not rs41279104) were associated with a weaker prepulse inhibition (PPI) of the acoustic startle reflex, a standard measure of sensorimotor gating. Furthermore, the effect of presence of risk variants in Ex1f- VNTR and rs6490121 was additive: PPI linearly decreased with increasing number of risk alleles, being highest in participants with no risk allele, while lowest in individuals who carry three risk alleles. Our findings indicate that NO is involved in the regulation of sensorimotor gating, and highlight one possible pathogenetic mechanism for NO playing a role in the development of schizophrenia psychosis.
ER  -

ROVNY, Rastislav, Martin MARKO, Stanislav KATINA, Jana MURINOVA, Veronika ROHARIKOVA, Barbora CIMROVA, Gabriela REPISKA, Gabriel MINARIK and Igor RIECANSKY. Association between genetic variability of neuronal nitric oxide synthase and sensorimotor gating in humans. \textit{NITRIC OXIDE-BIOLOGY AND CHEMISTRY}. Rochester, USA: Elsevier, 2018, vol.~80, No~1, p.~32-36. ISSN~1089-8603. Available from: https://dx.doi.org/10.1016/j.niox.2018.08.002.

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