The mystery of the cerebellum: clues from experimental and clinical observations

LAWRENSON, Charlotte, Martin BAREŠ, Anita KAMONDI, Andrea KOVÁCS, Bridget LUMB, Richard APPS, Pavel FILIP a Mario MANTO. The mystery of the cerebellum: clues from experimental and clinical observations. Cerebellum & ataxias. London: BioMed Central, roč. 5, č. 8, s. 1-11. ISSN 2053-8871. 2018.

Základní údaje

• Originální název: The mystery of the cerebellum: clues from experimental and clinical observations
• Autoři: LAWRENSON, Charlotte (826 Velká Británie a Severní Irsko), Martin BAREŠ (203 Česká republika, garant, domácí), Anita KAMONDI (348 Maďarsko), Andrea KOVÁCS (348 Maďarsko), Bridget LUMB (826 Velká Británie a Severní Irsko), Richard APPS (826 Velká Británie a Severní Irsko), Pavel FILIP (703 Slovensko, domácí) a Mario MANTO (56 Belgie).
• Vydání: Cerebellum & ataxias, London, BioMed Central, 2018, 2053-8871.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Článek v odborném periodiku
• Obor: 30210 Clinical neurology
• Stát vydavatele: Velká Británie a Severní Irsko
• Utajení: není předmětem státního či obchodního tajemství
• Kód RIV: RIV/00216224:14110/18:00103454
• Organizační jednotka: Lékařská fakulta
• Klíčová slova anglicky: Cerebellum; Anatomy; History; Fear; Cognition; Motor; Timing; Tremor
• Štítky: EL OK, rivok

Anotace

The cerebellum has a striking homogeneous cytoarchitecture and participates in both motor and non-motor domains. Indeed, a wealth of evidence from neuroanatomical, electrophysiological, neuroimaging and clinical studies has substantially modified our traditional view on the cerebellum as a sole calibrator of sensorimotor functions. Despite the major advances of the last four decades of cerebellar research, outstanding questions remain regarding the mechanisms and functions of the cerebellar circuitry. We discuss major clues from both experimental and clinical studies, with a focus on rodent models in fear behaviour, on the role of the cerebellum in motor control, on cerebellar contributions to timing and our appraisal of the pathogenesis of cerebellar tremor. The cerebellum occupies a central position to optimize behaviour, motor control, timing procedures and to prevent body oscillations. More than ever, the cerebellum is now considered as a major actor on the scene of disorders affecting the CMS, extending from motor disorders to cognitive and affective disorders. However, the respective roles of the mossy fibres, the climbing fibres, cerebellar cortex and cerebellar nuclei remains unknown or partially known at best in most cases. Research is now moving towards a better definition of the roles of cerebellar modules and microzones. This will impact on the management of cerebellar disorders.