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@article{1428821,
author = {Lawrenson, Charlotte and Bareš, Martin and Kamondi, Anita and Kovács, Andrea and Lumb, Bridget and Apps, Richard and Filip, Pavel and Manto, Mario},
article_location = {London},
article_number = {8},
doi = {http://dx.doi.org/10.1186/s40673-018-0087-9},
keywords = {Cerebellum; Anatomy; History; Fear; Cognition; Motor; Timing; Tremor},
language = {eng},
issn = {2053-8871},
journal = {Cerebellum and Ataxias},
title = {The mystery of the cerebellum: clues from experimental and clinical observations},
url = {https://link.springer.com/article/10.1186/s40673-018-0087-9?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot},
volume = {5},
year = {2018}
}
TY - JOUR
ID - 1428821
AU - Lawrenson, Charlotte - Bareš, Martin - Kamondi, Anita - Kovács, Andrea - Lumb, Bridget - Apps, Richard - Filip, Pavel - Manto, Mario
PY - 2018
TI - The mystery of the cerebellum: clues from experimental and clinical observations
JF - Cerebellum and Ataxias
VL - 5
IS - 8
SP - 1-11
EP - 1-11
PB - BioMed Central
SN - 20538871
KW - Cerebellum
KW - Anatomy
KW - History
KW - Fear
KW - Cognition
KW - Motor
KW - Timing
KW - Tremor
UR - https://link.springer.com/article/10.1186/s40673-018-0087-9?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot
N2 - The cerebellum has a striking homogeneous cytoarchitecture and participates in both motor and non-motor domains. Indeed, a wealth of evidence from neuroanatomical, electrophysiological, neuroimaging and clinical studies has substantially modified our traditional view on the cerebellum as a sole calibrator of sensorimotor functions. Despite the major advances of the last four decades of cerebellar research, outstanding questions remain regarding the mechanisms and functions of the cerebellar circuitry. We discuss major clues from both experimental and clinical studies, with a focus on rodent models in fear behaviour, on the role of the cerebellum in motor control, on cerebellar contributions to timing and our appraisal of the pathogenesis of cerebellar tremor. The cerebellum occupies a central position to optimize behaviour, motor control, timing procedures and to prevent body oscillations. More than ever, the cerebellum is now considered as a major actor on the scene of disorders affecting the CMS, extending from motor disorders to cognitive and affective disorders. However, the respective roles of the mossy fibres, the climbing fibres, cerebellar cortex and cerebellar nuclei remains unknown or partially known at best in most cases. Research is now moving towards a better definition of the roles of cerebellar modules and microzones. This will impact on the management of cerebellar disorders.
ER -
LAWRENSON, Charlotte, Martin BAREŠ, Anita KAMONDI, Andrea KOVÁCS, Bridget LUMB, Richard APPS, Pavel FILIP and Mario MANTO. The mystery of the cerebellum: clues from experimental and clinical observations. \textit{Cerebellum and Ataxias}. London: BioMed Central, 2018, vol.~5, No~8, p.~1-11. ISSN~2053-8871. Available from: https://dx.doi.org/10.1186/s40673-018-0087-9.
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