Detailed Information on Publication Record
2018
The mystery of the cerebellum: clues from experimental and clinical observations
LAWRENSON, Charlotte, Martin BAREŠ, Anita KAMONDI, Andrea KOVÁCS, Bridget LUMB et. al.Basic information
Original name
The mystery of the cerebellum: clues from experimental and clinical observations
Authors
LAWRENSON, Charlotte (826 United Kingdom of Great Britain and Northern Ireland), Martin BAREŠ (203 Czech Republic, guarantor, belonging to the institution), Anita KAMONDI (348 Hungary), Andrea KOVÁCS (348 Hungary), Bridget LUMB (826 United Kingdom of Great Britain and Northern Ireland), Richard APPS (826 United Kingdom of Great Britain and Northern Ireland), Pavel FILIP (703 Slovakia, belonging to the institution) and Mario MANTO (56 Belgium)
Edition
Cerebellum and Ataxias, London, BioMed Central, 2018, 2053-8871
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30210 Clinical neurology
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14110/18:00103454
Organization unit
Faculty of Medicine
Keywords in English
Cerebellum; Anatomy; History; Fear; Cognition; Motor; Timing; Tremor
Změněno: 23/4/2024 10:02, Mgr. Michal Petr
Abstract
V originále
The cerebellum has a striking homogeneous cytoarchitecture and participates in both motor and non-motor domains. Indeed, a wealth of evidence from neuroanatomical, electrophysiological, neuroimaging and clinical studies has substantially modified our traditional view on the cerebellum as a sole calibrator of sensorimotor functions. Despite the major advances of the last four decades of cerebellar research, outstanding questions remain regarding the mechanisms and functions of the cerebellar circuitry. We discuss major clues from both experimental and clinical studies, with a focus on rodent models in fear behaviour, on the role of the cerebellum in motor control, on cerebellar contributions to timing and our appraisal of the pathogenesis of cerebellar tremor. The cerebellum occupies a central position to optimize behaviour, motor control, timing procedures and to prevent body oscillations. More than ever, the cerebellum is now considered as a major actor on the scene of disorders affecting the CMS, extending from motor disorders to cognitive and affective disorders. However, the respective roles of the mossy fibres, the climbing fibres, cerebellar cortex and cerebellar nuclei remains unknown or partially known at best in most cases. Research is now moving towards a better definition of the roles of cerebellar modules and microzones. This will impact on the management of cerebellar disorders.