| KUNOVSKÝ, Lumír, Pavla TESARIKOVA, Zdeněk KALA, Radek KROUPA, Petr KYSELA, Jiří DOLINA a Jan TRNA. The Use of Biomarkers in Early Diagnostics of Pancreatic Cancer. Canadian Journal of Gastroenterology and Hepatology. New York: Hindawi Publishing Corporation, roč. 2018, č. 5389820, s. 1-10. ISSN 2291-2797. 2018. |
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@article{1429160,
author = {Kunovský, Lumír and Tesarikova, Pavla and Kala, Zdeněk and Kroupa, Radek and Kysela, Petr and Dolina, Jiří and Trna, Jan},
article_location = {New York},
article_number = {5389820},
keywords = {Pancreatic ductal adenocarcinoma},
language = {eng},
issn = {2291-2797},
journal = {Canadian Journal of Gastroenterology and Hepatology},
title = {The Use of Biomarkers in Early Diagnostics of Pancreatic Cancer},
volume = {2018},
year = {2018}
}
TY - JOUR
ID - 1429160
AU - Kunovský, Lumír - Tesarikova, Pavla - Kala, Zdeněk - Kroupa, Radek - Kysela, Petr - Dolina, Jiří - Trna, Jan
PY - 2018
TI - The Use of Biomarkers in Early Diagnostics of Pancreatic Cancer
JF - Canadian Journal of Gastroenterology and Hepatology
VL - 2018
IS - 5389820
SP - 1-10
EP - 1-10
PB - Hindawi Publishing Corporation
SN - 22912797
KW - Pancreatic ductal adenocarcinoma
N2 - Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies with increasing incidence. The poor prognosis is due to the aggressive nature of the tumor, late detection, and the resistance to chemotherapy and radiotherapy. A radical surgery procedure is the only treatment that has been shown to improve the 5-year survival rate to 20-25%. However, the majority of patients (80-85%) are diagnosed with locally advanced or metastatic disease and just 15-20% patients are diagnosed in an early stage allowing them to undergo the potentially curative surgical resection. The early detection of PDAC without the use of invasive methods is challenging and discovery of a cost-effective biomarker with high specificity and sensitivity could significantly improve the treatment and survival in these patients. In this review, we summarize current and newly examined biomarkers in early PDAC detection.
ER -
KUNOVSKÝ, Lumír, Pavla TESARIKOVA, Zdeněk KALA, Radek KROUPA, Petr KYSELA, Jiří DOLINA a Jan TRNA. The Use of Biomarkers in Early Diagnostics of Pancreatic Cancer. \textit{Canadian Journal of Gastroenterology and Hepatology}. New York: Hindawi Publishing Corporation, roč.~2018, č.~5389820, s.~1-10. ISSN~2291-2797. 2018.
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