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@article{1430518,
author = {Kraus, Jakub and Frick, Andreas and Fischer, Håkan and Howner, Katarina and Fredrikson, Mats and Furmark, Tomas},
article_location = {Clare},
article_number = {OCT 30 2018},
doi = {http://dx.doi.org/10.1016/j.pscychresns.2018.08.012},
keywords = {Social phobia; Emotional faces; International Affective Picture System; IAPS; fMRI; Fear},
language = {eng},
issn = {0925-4927},
journal = {PSYCHIATRY RESEARCH-NEUROIMAGING},
title = {Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder},
url = {https://www.sciencedirect.com/science/article/pii/S0925492718300659},
volume = {280},
year = {2018}
}
TY - JOUR
ID - 1430518
AU - Kraus, Jakub - Frick, Andreas - Fischer, Håkan - Howner, Katarina - Fredrikson, Mats - Furmark, Tomas
PY - 2018
TI - Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder
JF - PSYCHIATRY RESEARCH-NEUROIMAGING
VL - 280
IS - OCT 30 2018
SP - 56-61
EP - 56-61
PB - Elsevier Ireland
SN - 09254927
KW - Social phobia
KW - Emotional faces
KW - International Affective Picture System
KW - IAPS
KW - fMRI
KW - Fear
UR - https://www.sciencedirect.com/science/article/pii/S0925492718300659
N2 - Social anxiety disorder (SAD) is characterized by exaggerated amygdala reactivity in response to symptom provocation, but it is unclear if such hyper-reactivity is elicited by disorder-specific challenges only or characterizes reactions to aversive stimuli in general. Here, using functional magnetic resonance imaging in 14 patients with SAD, as compared to 12 healthy controls, we found that amygdala hyper-reactivity is confined to disorder-relevant social stimulation. SAD patients displayed increased amygdala reactivity to fearful as compared to neutral facial pictures, but not in response to generally aversive but mainly non-social stimulation when compared to neutral pictorial stimuli taken from the International Affective Picture System. The increased amygdala reactivity was not mediated by an altered prefrontal inhibition among SAD patients as compared to controls, suggesting increased bottom-up processes rather than attenuated top-down control. In conclusion, the enhanced amygdala reactivity in SAD seems specific to socially relevant stimuli rather than aversive stimuli in general.
ER -
KRAUS, Jakub, Andreas FRICK, Håkan FISCHER, Katarina HOWNER, Mats FREDRIKSON and Tomas FURMARK. Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder. \textit{PSYCHIATRY RESEARCH-NEUROIMAGING}. Clare: Elsevier Ireland, 2018, vol.~280, OCT 30 2018, p.~56-61. ISSN~0925-4927. Available from: https://dx.doi.org/10.1016/j.pscychresns.2018.08.012.
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