SUPEKAR, S., Anna PAPAGEORGIOU, G. GEMMECKER, R. PELTZER, M.P. JOHANSSON, Konstantinos TRIPSIANES, M. SATTLER and V.R.I. KAILA. Conformational Selection of Dimethylarginine Recognition by the Survival Motor Neuron Tudor Domain. Angewandte Chemie International Edition. WEINHEIM (GERMANY): Verlag Chemie, 2018, vol. 57, No 2, p. 486-490. ISSN 1433-7851. Available from: https://dx.doi.org/10.1002/anie.201708233.
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Basic information
Original name Conformational Selection of Dimethylarginine Recognition by the Survival Motor Neuron Tudor Domain
Authors SUPEKAR, S. (276 Germany), Anna PAPAGEORGIOU (300 Greece, belonging to the institution), G. GEMMECKER (276 Germany), R. PELTZER (276 Germany), M.P. JOHANSSON (578 Norway), Konstantinos TRIPSIANES (300 Greece, guarantor, belonging to the institution), M. SATTLER (276 Germany) and V.R.I. KAILA (276 Germany).
Edition Angewandte Chemie International Edition, WEINHEIM (GERMANY), Verlag Chemie, 2018, 1433-7851.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10402 Inorganic and nuclear chemistry
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 12.257
RIV identification code RIV/00216224:14740/18:00101121
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1002/anie.201708233
UT WoS 000419110500018
Keywords in English arginine rotation; cation-p interactions; dynamic NMR; QM/MM; quantum chemistry
Tags rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 18/3/2019 12:35.
Abstract
Tudor domains bind to dimethylarginine (DMA) residues, which are post-translational modifications that play a central role in gene regulation in eukaryotic cells. NMR spectroscopy and quantum calculations are combined to demonstrate that DMA recognition by Tudor domains involves conformational selection. The binding mechanism is confirmed by a mutation in the aromatic cage that perturbs the native recognition mode of the ligand. General mechanistic principles are delineated from the combined results, indicating that Tudor domains utilize cation-p interactions to achieve ligand recognition.
Links
GJ15-22380Y, research and development projectName: Molekulární stavba protein-DNA komplexů zapojených v opravě nukleotidových sestřihů
Investor: Czech Science Foundation
LQ1601, research and development projectName: CEITEC 2020 (Acronym: CEITEC2020)
Investor: Ministry of Education, Youth and Sports of the CR
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