Czech Republic can be perceived as a small EU Member states. As particularly Thorhallsson in his small states in the EU behavior model claims, small state should in their ordinary EU policy adopt specific approach consisting of for example prioritization in specific policy areas, flexible administration or focus on more intensive relations with the European Commission. The question is – how these assumptions hold if cross sectoral and continuous issue as Brexit (where expertise and experience of actors involved is minimal) is at stake? Do the EU small states follow pattern expected by their small states´ characteristics or can different behavior be identified? To answer this question, the paper analyses Brexit from the perspective of small EU Member states – here represented by the Czech Republic. It focuses on the process of national preferences formation (including actors and their involvement), the preferences themselves (content of national demands) and at the country´s involvement in the EU negotiations (including relations with the European Commission).