MARCIÁN, Václav, Radek MAREČEK, Eva KORIŤÁKOVÁ, Martin PAIL, Martin BAREŠ and Milan BRÁZDIL. Morphological changes of cerebellar substructures in temporal lobe epilepsy: A complex phenomenon, not mere atrophy. Online. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY. London: W B SAUNDERS CO LTD, 2018, vol. 54, JAN 2018, p. 51-57. ISSN 1059-1311. Available from: https://dx.doi.org/10.1016/j.seizure.2017.12.004. [citováno 2024-04-23]
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Basic information
Original name Morphological changes of cerebellar substructures in temporal lobe epilepsy: A complex phenomenon, not mere atrophy
Authors MARCIÁN, Václav (703 Slovakia, guarantor, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Eva KORIŤÁKOVÁ (203 Czech Republic, belonging to the institution), Martin PAIL (203 Czech Republic, belonging to the institution), Martin BAREŠ (203 Czech Republic, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, belonging to the institution)
Edition SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, London, W B SAUNDERS CO LTD, 2018, 1059-1311.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30210 Clinical neurology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.765
RIV identification code RIV/00216224:14110/18:00103600
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.seizure.2017.12.004
UT WoS 000424854100009
Keywords in English Epilepsy surgery outcome; AAL atlas; Clinical correlations
Tags 14110127, 14119612, EL OK, podil, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 12/3/2019 12:57.
Abstract
Purpose: To evaluate cerebellar volume changes in temporal lobe epilepsy (TLE) patients in greater detail. We aimed to determine which discrete substructures significantly differ in patients with TLE compared to controls and the nature of this difference. Correlations with age at epilepsy onset, epilepsy duration, seizure frequency, and total number of antiepileptic drugs (AED) in the patient's history were studied. We analyzed the potential association between cerebellar atrophy and epilepsy surgery outcome. Methods: Study participants were 36 TLE patients; 22 hippocampal sclerosis (HS) only and 38 healthy controls. All patients later underwent temporal lobe resection. All subjects were examined using 1.5T MRI. Cerebellar volume was adjusted for total intracranial volume, age, and gender, and measured using voxel-based morphometry. Cerebellar substructures were defined using the AAL atlas. Data processing was performed automatically. Separate analyses for HS only subset were performed. Results: Total cerebellar gray matter volume (GMV) appeared non-significantly smaller in epilepsy patients. Within the substructures, the GMV of the selected vermian segments were significantly larger in patients. The GMV of the whole cerebellum and of all individual cerebellar substructures non significantly decreased with increasing complex partial seizure frequency and total number of AEDs in the patient's history. Total cerebellar GMV was significantly smaller in patients with persistent seizures after epilepsy surgery than in seizure-free patients. Conclusion: Cerebellar atrophy is a complex phenomenon, the character of changes differs significantly within the cerebellar substructures. Total cerebellar GMV reduction is associated with worse outcome of temporal lobe resection.
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