Complex analyses of inverted repeats in mitochondrial genomes revealed their importance and variability

ČECHOVÁ, Jana, J LYSEK, M BARTAS and Václav BRÁZDA. Complex analyses of inverted repeats in mitochondrial genomes revealed their importance and variability. Bioinformatics. OXFORD: OXFORD UNIV PRESS, 2018, vol. 34, No 7, p. 1081-1085. ISSN 1367-4803. Available from: https://dx.doi.org/10.1093/bioinformatics/btx729.

Basic information

Original name

Complex analyses of inverted repeats in mitochondrial genomes revealed their importance and variability

Authors

ČECHOVÁ, Jana, J LYSEK, M BARTAS and Václav BRÁZDA

Edition

Bioinformatics, OXFORD, OXFORD UNIV PRESS, 2018, 1367-4803

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.531

DOI

http://dx.doi.org/10.1093/bioinformatics/btx729

UT WoS

000428840000001

Tags

RIV ne

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Abstract

V originále

Motivation: The NCBI database contains mitochondrial DNA (mtDNA) genomes from numerous species. We investigated the presence and locations of inverted repeat sequences (IRs) in these mtDNA sequences, which are known to be important for regulating nuclear genomes. Results: IRs were identified in mtDNA in all species. IR lengths and frequencies correlate with evolutionary age and the greatest variability was detected in subgroups of plants and fungi and the lowest variability in mammals. IR presence is non-random and evolutionary favoured. The frequency of IRs generally decreased with IR length, but not for IRs 24 or 30 bp long, which are 1.5 times more abundant. IRs are enriched in sequences from the replication origin, followed by D-loop, stem-loop and miscellaneous sequences, pointing to the importance of IRs in regulatory regions of mitochondrial DNA.