Detailed Information on Publication Record
2018
MicroRNAs in pathophysiology of acute myocardial infarction and cardiogenic shock
PÁVKOVÁ GOLDBERGOVÁ, Monika, Jolana LIPKOVÁ, Jan FEDORKO, Jana VEVERKOVÁ, Jiří PAŘENICA et. al.Basic information
Original name
MicroRNAs in pathophysiology of acute myocardial infarction and cardiogenic shock
Authors
PÁVKOVÁ GOLDBERGOVÁ, Monika (203 Czech Republic, belonging to the institution), Jolana LIPKOVÁ (203 Czech Republic, guarantor, belonging to the institution), Jan FEDORKO (203 Czech Republic, belonging to the institution), Jana VEVERKOVÁ (203 Czech Republic, belonging to the institution), Jiří PAŘENICA (203 Czech Republic, belonging to the institution), Jindřich ŠPINAR (203 Czech Republic, belonging to the institution), Michal MASAŘÍK (203 Czech Republic, belonging to the institution) and Anna VAŠKŮ (203 Czech Republic, belonging to the institution)
Edition
Bratislava Medical Journal - Bratislavské lekárske listy, Bratislava, Univerzita Komenského, 2018, 0006-9248
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30218 General and internal medicine
Country of publisher
Slovakia
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.859
RIV identification code
RIV/00216224:14110/18:00103638
Organization unit
Faculty of Medicine
UT WoS
000436626500004
Keywords in English
microRNA; STEMI; cardiogenic shock; prognosis
Tags
International impact, Reviewed
Změněno: 10/2/2019 16:05, Soňa Böhmová
Abstract
V originále
AIM: Levels of circulating miRNA are considered to be potential biomarkers of acute myocardial infarction and disease progression. METHODS: In this study, the expression levels of circulating miRNA-1, miRNA-133 and miRNA-124a were investigated in a group of patients with acute myocardial infarction (STEMI) and cardiogenic shock (CS) compared to controls. RESULTS: During the hospitalization period, miRNA-133 showed a significant up-regulation in the serum of STEMI and CS patients compared to controls, while the expression of miRNA-1 was significantly different only in CS. The expression of miRNA-124 was significantly higher in STEMI and CS. Furthermore, miRNA-1 expression was related to the level of circulating glucose in patients with STEMI. We also found a negative correlation between miRNA-133 and MMP-9 levels. MiRNA-124 expression was significantly related to the level of soluble ST2; the marker correlated to cardiac damage. CONCLUSION: All selected miRNAs are potential markers of cardiac injury in cardiogenic shock, whereas miRNA-124a and -133 are markers of injury in STEMI. MiRNA-1 expression is related to circulating glucose in STEMI. None of miRNAs could be correlated to the extent of injury, progress of the disease, or prognosis of patient outcome. Therefore, the levels of circulating miRNA have no potential for becoming a biomarker of myocardial damage and as such would bring no further benefit compared to current markers (Tab. 4, Fig. 1, Ref. 47).
Links
| MUNI/A/1401/2016, interní kód MU |
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