| LEGRAND, M., P.O. LUDES, Z. MASSY, P. ROSSIGNOL, Jiří PAŘENICA, J.J. PARK, S. ISHIHARA, K.F. ALHABIB, A. MAGGIONI, O. MIRO, N. SATO, A. COHEN-SOLAL, E. FAIRMAN, J. LASSUS, V.P. HARJOLA, C. MUELLER, F. PEACOCK, D.J. CHOI, P. PLAISANCE, Jindřich ŠPINAR, M. KOSIBOROD, A. MEBAZAA and E. GAYAT. Association between hypo- and hyperkalemia and outcome in acute heart failure patients: the role of medications. Clinical Research in Cardiology. Heidelberg: Springer, 2018, vol. 107, No 3, p. 214-221. ISSN 1861-0684. Available from: https://dx.doi.org/10.1007/s00392-017-1173-3. |
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@article{1435289,
author = {Legrand, M. and Ludes, P.O. and Massy, Z. and Rossignol, P. and Pařenica, Jiří and Park, J.J. and Ishihara, S. and AlHabib, K.F. and Maggioni, A. and Miro, O. and Sato, N. and CohenandSolal, A. and Fairman, E. and Lassus, J. and Harjola, V.P. and Mueller, C. and Peacock, F. and Choi, D.J. and Plaisance, P. and Špinar, Jindřich and Kosiborod, M. and Mebazaa, A. and Gayat, E.},
article_location = {Heidelberg},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s00392-017-1173-3},
keywords = {Mortality; Potassium; B-blockers; Heart failure; Renal failure},
language = {eng},
issn = {1861-0684},
journal = {Clinical Research in Cardiology},
title = {Association between hypo- and hyperkalemia and outcome in acute heart failure patients: the role of medications},
volume = {107},
year = {2018}
}
TY - JOUR
ID - 1435289
AU - Legrand, M. - Ludes, P.O. - Massy, Z. - Rossignol, P. - Pařenica, Jiří - Park, J.J. - Ishihara, S. - AlHabib, K.F. - Maggioni, A. - Miro, O. - Sato, N. - Cohen-Solal, A. - Fairman, E. - Lassus, J. - Harjola, V.P. - Mueller, C. - Peacock, F. - Choi, D.J. - Plaisance, P. - Špinar, Jindřich - Kosiborod, M. - Mebazaa, A. - Gayat, E.
PY - 2018
TI - Association between hypo- and hyperkalemia and outcome in acute heart failure patients: the role of medications
JF - Clinical Research in Cardiology
VL - 107
IS - 3
SP - 214-221
EP - 214-221
PB - Springer
SN - 18610684
KW - Mortality
KW - Potassium
KW - B-blockers
KW - Heart failure
KW - Renal failure
N2 - Background The interaction between chronic medications on admission and the association between serum potassium level and outcome in patients with acute heart failure (AHF) are unknown. Methods Observational intercontinental study of patients admitted with AHF. 15954 patients were included from 12 cohorts in 4 continents. Main outcome was 90-day mortality. Clinical presentation (medication use, hemodynamics, comorbidities), demographic, echocardiographic, and biochemical data on admission were recorded prospectively in each cohort, with prospective adjudication of outcomes. Results Positive and negative linear relationships between 90-day mortality and sK+ above 4.5 mmol/L (hyperkalemia) and below 3.5 mmol/L (hypo-kalemia) were observed. Hazard ratio for death was 1.46 [1.34-1.58] for hyperkalemia and 1.22 [1.06-1.40] for hypokalemia. In a fully adjusted model, only hyperkalemia remained associated with mortality (HR 1.03 [1.02-1.04] for each 0.1 mmol/l change of sK+ above 4.5 mmol/L). Interaction tests revealed that the association between hyperkalemia and outcome was significantly affected by chronic medications. The association between hyperkalemia and mortality was absent for patients treated with beta blockers and in those with preserved renal function. Conclusions In patients with AHF, sK+ > 4.5 mmol/L appears to be associated with 90-day mortality. B-blockers have potentially a protective effect in the setting of hyperkalemia.
ER -
LEGRAND, M., P.O. LUDES, Z. MASSY, P. ROSSIGNOL, Jiří PAŘENICA, J.J. PARK, S. ISHIHARA, K.F. ALHABIB, A. MAGGIONI, O. MIRO, N. SATO, A. COHEN-SOLAL, E. FAIRMAN, J. LASSUS, V.P. HARJOLA, C. MUELLER, F. PEACOCK, D.J. CHOI, P. PLAISANCE, Jindřich ŠPINAR, M. KOSIBOROD, A. MEBAZAA and E. GAYAT. Association between hypo- and hyperkalemia and outcome in acute heart failure patients: the role of medications. \textit{Clinical Research in Cardiology}. Heidelberg: Springer, 2018, vol.~107, No~3, p.~214-221. ISSN~1861-0684. Available from: https://dx.doi.org/10.1007/s00392-017-1173-3.
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