Detailed Information on Publication Record
2018
The accumulation of Liposomal Doxorubicin in tissues treated by radiofrequency ablation and irreversible electroporation in liver – in vivo experimental study on porcine models
JŮZA, Tomáš, Tomáš ANDRAŠINA, Josef JAROŠ, Tomáš ROHAN, Hiroko MARTIN et. al.Basic information
Original name
The accumulation of Liposomal Doxorubicin in tissues treated by radiofrequency ablation and irreversible electroporation in liver – in vivo experimental study on porcine models
Authors
JŮZA, Tomáš (203 Czech Republic, belonging to the institution), Tomáš ANDRAŠINA (703 Slovakia, belonging to the institution), Josef JAROŠ (203 Czech Republic, belonging to the institution), Tomáš ROHAN (203 Czech Republic, belonging to the institution), Hiroko MARTIN (840 United States of America, belonging to the institution), Martin Jakub ARBET (203 Czech Republic, belonging to the institution), Vlastimil VÁLEK (203 Czech Republic, belonging to the institution) and Nahum GOLDBERG
Edition
CIRSE 2018, 2018
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
30224 Radiology, nuclear medicine and medical imaging
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.928
RIV identification code
RIV/00216224:14110/18:00103796
Organization unit
Faculty of Medicine
ISSN
UT WoS
000446679300001
Keywords in English
irreversible electroporation; radiofrequency ablation; doxorubicine
Tags
International impact
Změněno: 31/5/2022 12:17, RNDr. Pavel Šmerk, Ph.D.
Abstract
V originále
Purpose To compare the accumulation of liposomal doxorubicin in liver tissue treated by radiofrequency ablation (RFA) and irreversible electroporation (IRE) in in vivo porcine models. Material and methods A total of 16 RFA and 16 IRE procedures were performed in the healthy livers of 2 groups of 3 pigs. RFA parameters included: StarBurstXL needle, 100W, and target temperature 105 °C for 7 min. One-hundred 100 µsec IRE pulses were delivered using 2 monopolar electrodes at 2250V at 1Hz. In each group, two pigs were administered MYOCET, 50mg (0.5mg/kg), while one pig served as a control. Sample harvesting from the central and peripheral zones of the ablation zones occurred at 24 and 72 hours. Doxorubicin concentrations were analyzed using fluorescence spectrofluorimetry of homogenized tissue. Results RFA treatment zones created with concomitant administration of doxorubicin were significantly larger than bland controls (2.5±0.3cm vs. 2.2±0.2cm) (p<0.05). By contrast, IRE treatments zones were negatively influenced by chemotherapy (2.2±0.4cm vs. 2.6±0.4cm) (p<0.05). At 24 hours, doxorubicin concentrations were significantly increased in comparison to untreated parenchyma in the peripheral and central zones of RFA (0,431±0,078µg/g and 0.314±0.055µg/g vs. 0.18±0,012µg/g) (p<0.05). Doxorubicin concentrations in IRE zones were not significantly different from untreated liver (0.191±0.049µg/g and 0.210±0.049µg/g vs. 0.18±0.012µg/g). Significant decreases in doxorubicin concentration were noted for RFA zones after 72 hours (0.366±0.088µg/g vs 0,22±0.044µg/g). There was no difference in doxorubicin concentration from 24 to 72 hours in IRE zones. Conclusion We observed increased accumulation of periprocedural doxorubicin following RFA, but a contrary effect when combined with IRE.
Links
| MUNI/A/1255/2017, interní kód MU |
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| MUNI/A/1298/2017, interní kód MU |
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| NV15-32484A, research and development project |
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