| HARAZIM, Hana, Pavel ŠTOURAČ, Petr JANKŮ, Hana ZELINKOVÁ, Kamil FRANK, Michal DUFEK and Petr ŠTOURAČ. Obstetric anesthesia/analgesia does not affect disease course in multiple sclerosis: 10-year retrospective cohort study. Brain and Behavior. Hoboken: Wiley, 2018, vol. 8, No 9, p. 1-9. ISSN 2162-3279. Available from: https://dx.doi.org/10.1002/brb3.1082. |
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@article{1442260,
author = {Harazim, Hana and Štourač, Pavel and Janků, Petr and Zelinková, Hana and Frank, Kamil and Dufek, Michal and Štourač, Petr},
article_location = {Hoboken},
article_number = {9},
doi = {http://dx.doi.org/10.1002/brb3.1082},
keywords = {cesarean section; labor; multiple sclerosis; obstetric anesthesia; pregnancy; relapse},
language = {eng},
issn = {2162-3279},
journal = {Brain and Behavior},
title = {Obstetric anesthesia/analgesia does not affect disease course in multiple sclerosis: 10-year retrospective cohort study},
volume = {8},
year = {2018}
}
TY - JOUR
ID - 1442260
AU - Harazim, Hana - Štourač, Pavel - Janků, Petr - Zelinková, Hana - Frank, Kamil - Dufek, Michal - Štourač, Petr
PY - 2018
TI - Obstetric anesthesia/analgesia does not affect disease course in multiple sclerosis: 10-year retrospective cohort study
JF - Brain and Behavior
VL - 8
IS - 9
SP - 1-9
EP - 1-9
PB - Wiley
SN - 21623279
KW - cesarean section
KW - labor
KW - multiple sclerosis
KW - obstetric anesthesia
KW - pregnancy
KW - relapse
N2 - Objectives: Multiple sclerosis (MS) often occurs in young women and the effect of obstetric anesthesia/analgesia on the disease is poorly understood. No previous study has investigated the course of the disease in women in labor in the Czech Republic. The aim of this study was to evaluate the occurrence or absence of relapses in the 6-month postpartum period in MS parturients with and without obstetric anesthesia/ analgesia. Materials and Methods: We retrospectively studied all deliveries (n = 58,455) at the University Hospital Brno from 2004 to 2013 and identified those of the women with an ICD-10 code G35 (MS) recorded anytime in their medical history (n = 428). We included only deliveries of women with confirmed diagnosis at the time of labor (n = 70). Statistical analysis was performed using the Fischer Exact Test. Results: There were 70 deliveries of 65 women, including 45 vaginal deliveries and 25 Cesarean deliveries (16 under general anesthesia, 8 with epidural anesthesia and 1 with spinal anesthesia). Epidural obstetric analgesia was performed in 11 deliveries. There was no statistically significant difference in relapses between the vaginal delivery group (n = 15; 33%) and Cesarean section group (n = 10; 40%), p = 0.611. Conclusion: Neither delivery mode (vaginal vs Caesarean) nor type of obstetric anesthesia/ analgesia was found to have any impact on the course of MS at 6 months postpartum in women with this condition.
ER -
HARAZIM, Hana, Pavel ŠTOURAČ, Petr JANKŮ, Hana ZELINKOVÁ, Kamil FRANK, Michal DUFEK and Petr ŠTOURAČ. Obstetric anesthesia/analgesia does not affect disease course in multiple sclerosis: 10-year retrospective cohort study. \textit{Brain and Behavior}. Hoboken: Wiley, 2018, vol.~8, No~9, p.~1-9. ISSN~2162-3279. Available from: https://dx.doi.org/10.1002/brb3.1082.
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