Obstetric anesthesia/analgesia does not affect disease course in multiple sclerosis: 10-year retrospective cohort study

HARAZIM, Hana, Pavel ŠTOURAČ, Petr JANKŮ, Hana ZELINKOVÁ, Kamil FRANK, Michal DUFEK and Petr ŠTOURAČ. Obstetric anesthesia/analgesia does not affect disease course in multiple sclerosis: 10-year retrospective cohort study. Brain and Behavior. Hoboken: Wiley, 2018, vol. 8, No 9, p. 1-9. ISSN 2162-3279. Available from: https://dx.doi.org/10.1002/brb3.1082.

Basic information

Original name

Obstetric anesthesia/analgesia does not affect disease course in multiple sclerosis: 10-year retrospective cohort study

Name in Czech

Porodnická anestezie/analgezie neovlivňuje průběh průběh onemocnění roztroušenou sklerózou: 10-letá retrospektivní observační studie

Authors

HARAZIM, Hana (703 Slovakia, belonging to the institution), Pavel ŠTOURAČ (203 Czech Republic, belonging to the institution), Petr JANKŮ (203 Czech Republic, belonging to the institution), Hana ZELINKOVÁ (203 Czech Republic, belonging to the institution), Kamil FRANK (203 Czech Republic, belonging to the institution), Michal DUFEK (203 Czech Republic, belonging to the institution) and Petr ŠTOURAČ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Brain and Behavior, Hoboken, Wiley, 2018, 2162-3279

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.072

RIV identification code

RIV/00216224:14110/18:00103828

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/brb3.1082

UT WoS

000445850000014

Keywords (in Czech)

císařský řez; porod; roztroušená skleróza; porodnická anestezie; těhotenství; relaps

Keywords in English

cesarean section; labor; multiple sclerosis; obstetric anesthesia; pregnancy; relapse

Tags

14110127, 14110221, 14110233, 14110322, 14110411, 14119612, rivok

Tags

International impact, Reviewed

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Abstract

V originále

Objectives: Multiple sclerosis (MS) often occurs in young women and the effect of obstetric anesthesia/analgesia on the disease is poorly understood. No previous study has investigated the course of the disease in women in labor in the Czech Republic. The aim of this study was to evaluate the occurrence or absence of relapses in the 6-month postpartum period in MS parturients with and without obstetric anesthesia/ analgesia. Materials and Methods: We retrospectively studied all deliveries (n = 58,455) at the University Hospital Brno from 2004 to 2013 and identified those of the women with an ICD-10 code G35 (MS) recorded anytime in their medical history (n = 428). We included only deliveries of women with confirmed diagnosis at the time of labor (n = 70). Statistical analysis was performed using the Fischer Exact Test. Results: There were 70 deliveries of 65 women, including 45 vaginal deliveries and 25 Cesarean deliveries (16 under general anesthesia, 8 with epidural anesthesia and 1 with spinal anesthesia). Epidural obstetric analgesia was performed in 11 deliveries. There was no statistically significant difference in relapses between the vaginal delivery group (n = 15; 33%) and Cesarean section group (n = 10; 40%), p = 0.611. Conclusion: Neither delivery mode (vaginal vs Caesarean) nor type of obstetric anesthesia/ analgesia was found to have any impact on the course of MS at 6 months postpartum in women with this condition.

In Czech

Článek popisuje výsledky 10-letého auditu porodnické anestezie a analgezie ve vztahu k průběhu onemocnění roztroušenou sklerózou. Na míru relapsů onemocnění neměla porodnická anestezie či analgezie vliv.