| RUDÁ, Jana, Petra AMCHOVÁ, Alena MÁCHALOVÁ, Jana PISTOVČÁKOVÁ and Alexandra ŠULCOVÁ. PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE. Psychiatria danubina. Zagreb: Medicinska naklada Zagreb, 2018, vol. 30, No 3, p. 356-366. ISSN 0353-5053. Available from: https://dx.doi.org/10.24869/psyd.2018.356. |
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@article{1443237,
author = {Rudá, Jana and Amchová, Petra and Máchalová, Alena and Pistovčáková, Jana and Šulcová, Alexandra},
article_location = {Zagreb},
article_number = {3},
doi = {http://dx.doi.org/10.24869/psyd.2018.356},
keywords = {modafinil; prenatal administration; locomotion; phagocytosis; mice},
language = {eng},
issn = {0353-5053},
journal = {Psychiatria danubina},
title = {PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE},
volume = {30},
year = {2018}
}
TY - JOUR
ID - 1443237
AU - Rudá, Jana - Amchová, Petra - Máchalová, Alena - Pistovčáková, Jana - Šulcová, Alexandra
PY - 2018
TI - PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE
JF - Psychiatria danubina
VL - 30
IS - 3
SP - 356-366
EP - 356-366
PB - Medicinska naklada Zagreb
SN - 03535053
KW - modafinil
KW - prenatal administration
KW - locomotion
KW - phagocytosis
KW - mice
N2 - Background: Modafinil is a psychostimulant drug prescribed mainly for treatment of narcolepsy but is used as a "smart drug" by wide populations to increase wakefulness, concentration and overall mental performance. The aim of this study was to assess potential developmental toxicity of modafinil. Materials and methods: Pregnant female mice were given either saline or modafinil (50 mg/kg orally) from gestational day (GD) 3 to GD 10 and then a challenge dose on the GD 17. The male offspring were treated analogously at the age of 10 weeks. Changes in the spontaneous locomotor/exploratory behaviour and anxiogenic profile in the open-field test were assessed in naive animals, after an acute and 8th modafinil dose and the challenge dose following a 7-day wash-out period. One month after completion of the behavioural study, the leukocyte phagocytosis was examined by zymosan induced and luminol-aided chemiluminiscence assay in vitro. Results: The most important finding of this study was the immunosuppressing effect on leukocyte activity, hypolocomotion and increased behavioural response to modafinil-induced psychostimulation caused by prenatal exposure to the same drug. We did not detect significantly altered anxiety-related behaviour in any group disregarding the pre- and postnatal treatments. Conclusion: This is the first evidence of developmental toxicity of modafinil which needs to be taken into account as a potential risk factor when modafinil is administered to women who may become or are pregnant.
ER -
RUDÁ, Jana, Petra AMCHOVÁ, Alena MÁCHALOVÁ, Jana PISTOVČÁKOVÁ and Alexandra ŠULCOVÁ. PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE. \textit{Psychiatria danubina}. Zagreb: Medicinska naklada Zagreb, 2018, vol.~30, No~3, p.~356-366. ISSN~0353-5053. Available from: https://dx.doi.org/10.24869/psyd.2018.356.
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