Detailed Information on Publication Record
2018
PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE
RUDÁ, Jana, Petra AMCHOVÁ, Alena MÁCHALOVÁ, Jana PISTOVČÁKOVÁ, Alexandra ŠULCOVÁ et. al.Basic information
Original name
PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE
Name in Czech
Prenatální expozice modafinilu ovlivňuje lokomoci a leukocytární fagocytózu u myších samců
Authors
RUDÁ, Jana (203 Czech Republic, guarantor, belonging to the institution), Petra AMCHOVÁ (203 Czech Republic, belonging to the institution), Alena MÁCHALOVÁ (203 Czech Republic, belonging to the institution), Jana PISTOVČÁKOVÁ (203 Czech Republic, belonging to the institution) and Alexandra ŠULCOVÁ (203 Czech Republic, belonging to the institution)
Edition
Psychiatria danubina, Zagreb, Medicinska naklada Zagreb, 2018, 0353-5053
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
Croatia
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.683
RIV identification code
RIV/00216224:14110/18:00103872
Organization unit
Faculty of Medicine
UT WoS
000445798700014
Keywords in English
modafinil; prenatal administration; locomotion; phagocytosis; mice
Tags
International impact, Reviewed
Změněno: 26/3/2019 10:45, Soňa Böhmová
Abstract
V originále
Background: Modafinil is a psychostimulant drug prescribed mainly for treatment of narcolepsy but is used as a "smart drug" by wide populations to increase wakefulness, concentration and overall mental performance. The aim of this study was to assess potential developmental toxicity of modafinil. Materials and methods: Pregnant female mice were given either saline or modafinil (50 mg/kg orally) from gestational day (GD) 3 to GD 10 and then a challenge dose on the GD 17. The male offspring were treated analogously at the age of 10 weeks. Changes in the spontaneous locomotor/exploratory behaviour and anxiogenic profile in the open-field test were assessed in naive animals, after an acute and 8th modafinil dose and the challenge dose following a 7-day wash-out period. One month after completion of the behavioural study, the leukocyte phagocytosis was examined by zymosan induced and luminol-aided chemiluminiscence assay in vitro. Results: The most important finding of this study was the immunosuppressing effect on leukocyte activity, hypolocomotion and increased behavioural response to modafinil-induced psychostimulation caused by prenatal exposure to the same drug. We did not detect significantly altered anxiety-related behaviour in any group disregarding the pre- and postnatal treatments. Conclusion: This is the first evidence of developmental toxicity of modafinil which needs to be taken into account as a potential risk factor when modafinil is administered to women who may become or are pregnant.
Links
| MUNI/A/1132/2017, interní kód MU |
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