Enhanced bioactivity of electrospun PCL and PLLA scaffolds blended with amino-phosphazene

SEDLÁKOVÁ, Veronika, Zbyněk VORÁČ, Josef JAROŠ, Radka KOPECKÁ, Michaela KLOUČKOVÁ, Michal SVOBODA, Libor STREIT, Jana DUMKOVÁ, Kateřina VAŠÍČKOVÁ, Milan ALBERTI and Aleš HAMPL. Enhanced bioactivity of electrospun PCL and PLLA scaffolds blended with amino-phosphazene. Materials Letters. Amsterdam: Elsevier Science, 2018, vol. 228, OCT 1 2018, p. 339-343. ISSN 0167-577X. Available from: https://dx.doi.org/10.1016/j.matlet.2018.06.023.

Basic information

• Original name: Enhanced bioactivity of electrospun PCL and PLLA scaffolds blended with amino-phosphazene
• Authors: SEDLÁKOVÁ, Veronika (203 Czech Republic, belonging to the institution), Zbyněk VORÁČ (203 Czech Republic, belonging to the institution), Josef JAROŠ (203 Czech Republic, belonging to the institution), Radka KOPECKÁ (203 Czech Republic, belonging to the institution), Michaela KLOUČKOVÁ (203 Czech Republic, belonging to the institution), Michal SVOBODA (203 Czech Republic, belonging to the institution), Libor STREIT (203 Czech Republic, belonging to the institution), Jana DUMKOVÁ (203 Czech Republic, belonging to the institution), Kateřina VAŠÍČKOVÁ (203 Czech Republic, belonging to the institution), Milan ALBERTI (203 Czech Republic, belonging to the institution) and Aleš HAMPL (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Materials Letters, Amsterdam, Elsevier Science, 2018, 0167-577X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30404 Biomaterials
• Country of publisher: Netherlands
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.019
• RIV identification code: RIV/00216224:14110/18:00103938
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.matlet.2018.06.023
• UT WoS: 000439045500086
• Keywords in English: Phosphazene; Amino; Electrospinning; Biomaterials; Biomimetic; Morphology
• Tags: 14110128, 14110517, 14119612, podil, rivok
• Tags: International impact, Reviewed

Abstract

Here we report for the first time that blending hexaamino-cyclo-triphosphazene with either poly-epsilon-caprolactone or poly-L-lactic acid enables the generation of blended electrospun scaffolds with enhanced bioactivities. These hexaamino-cyclo-triphosphazene-modified fibers significantly promote cell adhesion, spreading, metabolism, and proliferation. In addition to that we also report more efficient hexaaminocyclo-triphosphazene synthesis with a higher yield and purity.

Links

• LD15144, research and development project: Name: Buněčné a nebuněčné základy pro regeneraci kostí a zubů (Acronym: TissueENG)

Investor: Ministry of Education, Youth and Sports of the CR

• MUNI/A/1369/2016, interní kód MU: Name: Zdroje pro tkáňové inženýrství 7 (Acronym: TissueENG 7)

Investor: Masaryk University, Category A

• NV16-31501A, research and development project: Name: Tkáňové inženýrství epitelů: Buňky a protokoly pro regenerativní medicínu