Aldosterone and aldosterone/cortisol ratio is higher in serum
of long-term compared to first episode schizophrenia patients:
A pilot study

J 2018

Aldosterone and aldosterone/cortisol ratio is higher in serum of long-term compared to first episode schizophrenia patients: A pilot study

USTOHAL, Libor, N. HLAVACOVA, Michaela MAYEROVÁ, Eva ČEŠKOVÁ, D. JEZOVA et. al.

Basic information

Original name

Aldosterone and aldosterone/cortisol ratio is higher in serum of long-term compared to first episode schizophrenia patients: A pilot study

Authors

USTOHAL, Libor (203 Czech Republic, belonging to the institution), N. HLAVACOVA (203 Czech Republic), Michaela MAYEROVÁ (203 Czech Republic, belonging to the institution), Eva ČEŠKOVÁ (203 Czech Republic, belonging to the institution) and D. JEZOVA (203 Czech Republic, guarantor)

Edition

Journal of Psychiatric Research, OXFORD, Elsevier, 2018, 0022-3956

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30215 Psychiatry

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.917

RIV identification code

RIV/00216224:14110/18:00103966

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.jpsychires.2018.06.012

UT WoS

000443788300007

Keywords in English

Aldosterone; Cortisol; First episode; Long-term schizophrenia

Abstract

V originále

We have previously shown that patients with severe depressive episode exhibit higher aldosterone concentrations compared to those with moderate depressive episode. The present study was undertaken to test the hypothesis that circulating concentration of aldosterone reflect the clinical state in patients with schizophrenia. The sample consisted of 36 hospitalized patients (25 men, 11 women) with the first episode or long-term course of schizophrenia. The severity of psychopathology was evaluated using the Positive and Negative Syndrome Scale (PANSS). Samples for measurement of serum aldosterone were obtained immediately after awakening. The results showed that serum aldosterone concentrations were lower in patients with the first episode compared to those in patients with long-term course of schizophrenia. Importantly, lower aldosterone concentrations observed in patients with the first episode were associated with more severe clinical symptoms as indicated by all subscales of PANSS. Serum cortisol concentrations did not differ between the groups, while the aldosterone/cortisol ratio showed similar pattern as aldosterone concentrations. The present pilot study suggests that circulating aldosterone in patients with schizophrenia may reflect the severity of clinical symptoms but in an opposite direction than in patients with major depressive disorder.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

USTOHAL, Libor, N. HLAVACOVA, Michaela MAYEROVÁ, Eva ČEŠKOVÁ and D. JEZOVA. Aldosterone and aldosterone/cortisol ratio is higher in serum of long-term compared to first episode schizophrenia patients: A pilot study. Journal of Psychiatric Research. OXFORD: Elsevier, 2018, vol. 104, SEP 2018, p. 46-49. ISSN 0022-3956. Available from: https://dx.doi.org/10.1016/j.jpsychires.2018.06.012.

@article{1446676,
   author = {Ustohal, Libor and Hlavacova, N. and Mayerová, Michaela and Češková, Eva and Jezova, D.},
   article_location = {OXFORD},
   article_number = {SEP 2018},
   doi = {http://dx.doi.org/10.1016/j.jpsychires.2018.06.012},
   keywords = {Aldosterone; Cortisol; First episode; Long-term schizophrenia},
   language = {eng},
   issn = {0022-3956},
   journal = {Journal of Psychiatric Research},
   title = {Aldosterone and aldosterone/cortisol ratio is higher in serum of long-term compared to first episode schizophrenia patients: A pilot study},
   volume = {104},
   year = {2018}
}

TY  - JOUR
ID  - 1446676
AU  - Ustohal, Libor - Hlavacova, N. - Mayerová, Michaela - Češková, Eva - Jezova, D.
PY  - 2018
TI  - Aldosterone and aldosterone/cortisol ratio is higher in serum of long-term compared to first episode schizophrenia patients: A pilot study
JF  - Journal of Psychiatric Research
VL  - 104
IS  - SEP 2018
SP  - 46-49
EP  - 46-49
PB  - Elsevier
SN  - 00223956
KW  - Aldosterone
KW  - Cortisol
KW  - First episode
KW  - Long-term schizophrenia
N2  - We have previously shown that patients with severe depressive episode exhibit higher aldosterone concentrations compared to those with moderate depressive episode. The present study was undertaken to test the hypothesis that circulating concentration of aldosterone reflect the clinical state in patients with schizophrenia. The sample consisted of 36 hospitalized patients (25 men, 11 women) with the first episode or long-term course of schizophrenia. The severity of psychopathology was evaluated using the Positive and Negative Syndrome Scale (PANSS). Samples for measurement of serum aldosterone were obtained immediately after awakening. The results showed that serum aldosterone concentrations were lower in patients with the first episode compared to those in patients with long-term course of schizophrenia. Importantly, lower aldosterone concentrations observed in patients with the first episode were associated with more severe clinical symptoms as indicated by all subscales of PANSS. Serum cortisol concentrations did not differ between the groups, while the aldosterone/cortisol ratio showed similar pattern as aldosterone concentrations. The present pilot study suggests that circulating aldosterone in patients with schizophrenia may reflect the severity of clinical symptoms but in an opposite direction than in patients with major depressive disorder.
ER  -

USTOHAL, Libor, N. HLAVACOVA, Michaela MAYEROVÁ, Eva ČEŠKOVÁ and D. JEZOVA. Aldosterone and aldosterone/cortisol ratio is higher in serum of long-term compared to first episode schizophrenia patients: A pilot study. \textit{Journal of Psychiatric Research}. OXFORD: Elsevier, 2018, vol.~104, SEP 2018, p.~46-49. ISSN~0022-3956. Available from: https://dx.doi.org/10.1016/j.jpsychires.2018.06.012.

Detailed Information on Publication Record