Detailed Information on Publication Record
2018
Aldosterone and aldosterone/cortisol ratio is higher in serum of long-term compared to first episode schizophrenia patients: A pilot study
USTOHAL, Libor, N. HLAVACOVA, Michaela MAYEROVÁ, Eva ČEŠKOVÁ, D. JEZOVA et. al.Basic information
Original name
Aldosterone and aldosterone/cortisol ratio is higher in serum of long-term compared to first episode schizophrenia patients: A pilot study
Authors
USTOHAL, Libor (203 Czech Republic, belonging to the institution), N. HLAVACOVA (203 Czech Republic), Michaela MAYEROVÁ (203 Czech Republic, belonging to the institution), Eva ČEŠKOVÁ (203 Czech Republic, belonging to the institution) and D. JEZOVA (203 Czech Republic, guarantor)
Edition
Journal of Psychiatric Research, OXFORD, Elsevier, 2018, 0022-3956
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30215 Psychiatry
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 3.917
RIV identification code
RIV/00216224:14110/18:00103966
Organization unit
Faculty of Medicine
UT WoS
000443788300007
Keywords in English
Aldosterone; Cortisol; First episode; Long-term schizophrenia
Tags
International impact, Reviewed
Změněno: 4/3/2019 09:53, Mgr. Pavla Foltynová, Ph.D.
Abstract
V originále
We have previously shown that patients with severe depressive episode exhibit higher aldosterone concentrations compared to those with moderate depressive episode. The present study was undertaken to test the hypothesis that circulating concentration of aldosterone reflect the clinical state in patients with schizophrenia. The sample consisted of 36 hospitalized patients (25 men, 11 women) with the first episode or long-term course of schizophrenia. The severity of psychopathology was evaluated using the Positive and Negative Syndrome Scale (PANSS). Samples for measurement of serum aldosterone were obtained immediately after awakening. The results showed that serum aldosterone concentrations were lower in patients with the first episode compared to those in patients with long-term course of schizophrenia. Importantly, lower aldosterone concentrations observed in patients with the first episode were associated with more severe clinical symptoms as indicated by all subscales of PANSS. Serum cortisol concentrations did not differ between the groups, while the aldosterone/cortisol ratio showed similar pattern as aldosterone concentrations. The present pilot study suggests that circulating aldosterone in patients with schizophrenia may reflect the severity of clinical symptoms but in an opposite direction than in patients with major depressive disorder.
Links
| LQ1601, research and development project |
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