| MAYEROVÁ, Michaela, Libor USTOHAL, Jiří JARKOVSKÝ, Jan PIVNIČKA, Tomáš KAŠPÁREK and Eva ČEŠKOVÁ. Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations. Neuropsychiatric Disease and Treatment. Auckland: Dove Medical Press Ltd., 2018, vol. 14, No 2018, p. 1535-1543. ISSN 1178-2021. Available from: https://dx.doi.org/10.2147/NDT.S163839. |
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@article{1446716,
author = {Mayerová, Michaela and Ustohal, Libor and Jarkovský, Jiří and Pivnička, Jan and Kašpárek, Tomáš and Češková, Eva},
article_location = {Auckland},
article_number = {2018},
doi = {http://dx.doi.org/10.2147/NDT.S163839},
keywords = {therapeutic drug monitoring; plasma levels; interindividual variability; schizophrenia; schizoaffective disorder},
language = {eng},
issn = {1178-2021},
journal = {Neuropsychiatric Disease and Treatment},
title = {Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations},
volume = {14},
year = {2018}
}
TY - JOUR
ID - 1446716
AU - Mayerová, Michaela - Ustohal, Libor - Jarkovský, Jiří - Pivnička, Jan - Kašpárek, Tomáš - Češková, Eva
PY - 2018
TI - Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations
JF - Neuropsychiatric Disease and Treatment
VL - 14
IS - 2018
SP - 1535-1543
EP - 1535-1543
PB - Dove Medical Press Ltd.
SN - 11782021
KW - therapeutic drug monitoring
KW - plasma levels
KW - interindividual variability
KW - schizophrenia
KW - schizoaffective disorder
N2 - Introduction: Therapeutic drug monitoring (TDM) of clozapine is a very useful method for verifying both the correct intake and the interindividual variability of its metabolism, thereby avoiding the risk of toxicity. The purposes of this paper were to discover how many patients using clozapine in common clinical practice have clozapine plasma concentration (PC) levels in the proposed reference range and to identify factors that influence clozapine PC levels. Methods: Our study included 100 inpatients (diagnosed with schizophrenia or schizoaffective disorder) taking standard doses of clozapine (100-700 mg/day). Clozapine concentration was measured by high-performance liquid chromatography. Correlations between doses and PC levels and the influence of smoking and gender on clozapine PC levels were calculated. Results: A large number of the patients (67%) had PC levels outside the proposed reference range. The clozapine PC levels were influenced by dose, gender, and cigarette smoking. Conclusion: The correlations between dose, gender, and cigarette smoking and clozapine PC levels highlighted by our study overlap other research. It was surprising to find such a large number of patients with clozapine PC levels outside the therapeutic range. This result suggests the importance of clozapine TDM due to misunderstood inter-and/or intraindividual variability or misestimated partial therapeutic compliance.
ER -
MAYEROVÁ, Michaela, Libor USTOHAL, Jiří JARKOVSKÝ, Jan PIVNIČKA, Tomáš KAŠPÁREK and Eva ČEŠKOVÁ. Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations. \textit{Neuropsychiatric Disease and Treatment}. Auckland: Dove Medical Press Ltd., 2018, vol.~14, No~2018, p.~1535-1543. ISSN~1178-2021. Available from: https://dx.doi.org/10.2147/NDT.S163839.
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