Detailed Information on Publication Record
2018
Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations
MAYEROVÁ, Michaela, Libor USTOHAL, Jiří JARKOVSKÝ, Jan PIVNIČKA, Tomáš KAŠPÁREK et. al.Basic information
Original name
Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations
Authors
MAYEROVÁ, Michaela (203 Czech Republic, belonging to the institution), Libor USTOHAL (203 Czech Republic, guarantor, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Jan PIVNIČKA (203 Czech Republic, belonging to the institution), Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution) and Eva ČEŠKOVÁ (203 Czech Republic, belonging to the institution)
Edition
Neuropsychiatric Disease and Treatment, Auckland, Dove Medical Press Ltd. 2018, 1178-2021
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30215 Psychiatry
Country of publisher
New Zealand
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.228
RIV identification code
RIV/00216224:14110/18:00103968
Organization unit
Faculty of Medicine
UT WoS
000435877800001
Keywords in English
therapeutic drug monitoring; plasma levels; interindividual variability; schizophrenia; schizoaffective disorder
Tags
International impact, Reviewed
Změněno: 2/5/2019 14:02, Soňa Böhmová
Abstract
V originále
Introduction: Therapeutic drug monitoring (TDM) of clozapine is a very useful method for verifying both the correct intake and the interindividual variability of its metabolism, thereby avoiding the risk of toxicity. The purposes of this paper were to discover how many patients using clozapine in common clinical practice have clozapine plasma concentration (PC) levels in the proposed reference range and to identify factors that influence clozapine PC levels. Methods: Our study included 100 inpatients (diagnosed with schizophrenia or schizoaffective disorder) taking standard doses of clozapine (100-700 mg/day). Clozapine concentration was measured by high-performance liquid chromatography. Correlations between doses and PC levels and the influence of smoking and gender on clozapine PC levels were calculated. Results: A large number of the patients (67%) had PC levels outside the proposed reference range. The clozapine PC levels were influenced by dose, gender, and cigarette smoking. Conclusion: The correlations between dose, gender, and cigarette smoking and clozapine PC levels highlighted by our study overlap other research. It was surprising to find such a large number of patients with clozapine PC levels outside the therapeutic range. This result suggests the importance of clozapine TDM due to misunderstood inter-and/or intraindividual variability or misestimated partial therapeutic compliance.
Links
| LQ1601, research and development project |
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| NV15-31063A, research and development project |
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