| STANÍK, Michal, Alexandr POPRACH, D. MACIK, I. CAPAK, Denisa KREJČÍ, N. MARECKOVA, Radek LAKOMÝ, Jiří JARKOVSKÝ and Jan DOLEŽEL. Clinically node-positive bladder cancer: oncological results of induction chemotherapy and consolidative surgery. Neoplasma. Bratislava: Slovenská akademie vied, 2018, vol. 65, No 2, p. 287-291. ISSN 0028-2685. Available from: https://dx.doi.org/10.4149/neo_2018_170403N239. |
Other formats:
BibTeX
LaTeX
RIS
@article{1449896,
author = {Staník, Michal and Poprach, Alexandr and Macik, D. and Capak, I. and Krejčí, Denisa and Mareckova, N. and Lakomý, Radek and Jarkovský, Jiří and Doležel, Jan},
article_location = {Bratislava},
article_number = {2},
doi = {http://dx.doi.org/10.4149/neo_2018_170403N239},
keywords = {urinary bladder neoplasms; lymphadenopathy; combined modality therapy; induction chemotherapy; cystectomy},
language = {eng},
issn = {0028-2685},
journal = {Neoplasma},
title = {Clinically node-positive bladder cancer: oncological results of induction chemotherapy and consolidative surgery},
volume = {65},
year = {2018}
}
TY - JOUR
ID - 1449896
AU - Staník, Michal - Poprach, Alexandr - Macik, D. - Capak, I. - Krejčí, Denisa - Mareckova, N. - Lakomý, Radek - Jarkovský, Jiří - Doležel, Jan
PY - 2018
TI - Clinically node-positive bladder cancer: oncological results of induction chemotherapy and consolidative surgery
JF - Neoplasma
VL - 65
IS - 2
SP - 287-291
EP - 287-291
PB - Slovenská akademie vied
SN - 00282685
KW - urinary bladder neoplasms
KW - lymphadenopathy
KW - combined modality therapy
KW - induction chemotherapy
KW - cystectomy
N2 - Patients with clinically node-positive bladder cancer have a poor prognosis, with many receiving only palliative chemotherapy. We evaluated oncological results in bladder cancer patients with clinically regional and supraregional lymphadenopathy treated with induction chemotherapy (IC) and consolidative cystectomy. Twenty-five patients with clinically node-positive bladder cancer (including pelvic and retroperitoneal nodes) were treated with 2-4 cycles of IC followed by consolidative cystectomy between 2010 and 2016. Pathologic complete response (pCR) was defined as no residual tumor in the final specimen (ypT0N0). The 3-year cancer-specific (CSS) and recurrence-free survival (RFS) for the whole cohort were 52% and 39%, respectively. The 3-year RFS differed according to volume of nodal metastases, the rates were 56% for minimal nodal disease (cN1) versus 33% for cN2-3 and 0% for cM1 disease (p<0.001). pCR was seen in 7 (28%) patients; 50% in cN1 versus 13% in cN3-M1. pCR associated with 3-year CSS of 80% versus 45% in patients with persistent disease aft er IC. In conclusion, a multimodal approach to patients with clinically node-positive bladder cancer, consisting of IC followed by consolidative surgery, may achieve long-term survival in selected patients. Better results may be expected in patients with initially minimal nodal burden and complete pathologic response to chemotherapy. Further studies are warranted to improve patient selection for consolidative surgery, especially with supra-regional metastases.
ER -
STANÍK, Michal, Alexandr POPRACH, D. MACIK, I. CAPAK, Denisa KREJČÍ, N. MARECKOVA, Radek LAKOMÝ, Jiří JARKOVSKÝ and Jan DOLEŽEL. Clinically node-positive bladder cancer: oncological results of induction chemotherapy and consolidative surgery. \textit{Neoplasma}. Bratislava: Slovenská akademie vied, 2018, vol.~65, No~2, p.~287-291. ISSN~0028-2685. Available from: https://dx.doi.org/10.4149/neo\_{}2018\_{}170403N239.
|
