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@article{1450096,
author = {Pavlová, Tereza and Zlámal, Filip and Tomandl, Josef and Hodická, Zuzana and Gulati, Sumeet and Bienertová Vašků, Julie},
article_location = {London},
article_number = {7628957},
doi = {http://dx.doi.org/10.1155/2018/7628957},
keywords = {Irisin},
language = {eng},
issn = {0278-0240},
journal = {Disease Markers},
title = {Irisin Maternal Plasma and Cord Blood Levels in Mothers with Spontaneous Preterm and Term Delivery},
volume = {2018},
year = {2018}
}
TY - JOUR
ID - 1450096
AU - Pavlová, Tereza - Zlámal, Filip - Tomandl, Josef - Hodická, Zuzana - Gulati, Sumeet - Bienertová Vašků, Julie
PY - 2018
TI - Irisin Maternal Plasma and Cord Blood Levels in Mothers with Spontaneous Preterm and Term Delivery
JF - Disease Markers
VL - 2018
IS - 7628957
SP - 1-9
EP - 1-9
PB - Hindawi Publishing Corporation
SN - 02780240
KW - Irisin
N2 - Irisin, an adipomyokine identified in 2012, has been investigated in association with common pregnancy complications, including gestational diabetes mellitus, preeclampsia, and intrauterine growth restriction. The objective of this study is to examine the potential role of irisin in preterm birth (PTB) by comparing its level between mothers with term and preterm labor. Maternal peripheral blood and cord blood samples were collected from 30 mothers who delivered prematurely and from 35 mothers who delivered at term. Irisin concentrations were measured in all samples using ELISA, and four common single nucleotide polymorphisms in the irisin gene were determined (rs16835198, rs726344, rs3480, and rs1746661). Univariable and multivariable regression modeling was applied to evaluate maternal and cord blood irisin concentrations in relation to preterm/term labor. Irisin concentration in umbilical cord blood was found to be associated with PTB in the univariable model (p = 0.046). On the other hand, no differences in maternal blood irisin levels between mothers with preterm and term deliveries were established. To the best of our knowledge, this is the first study determining irisin levels in term and preterm deliveries in maternal peripheral blood and umbilical cord blood. Our study shows a possible association between cord blood irisin concentration and PTB occurrence.
ER -
PAVLOVÁ, Tereza, Filip ZLÁMAL, Josef TOMANDL, Zuzana HODICKÁ, Sumeet GULATI and Julie BIENERTOVÁ VAŠKŮ. Irisin Maternal Plasma and Cord Blood Levels in Mothers with Spontaneous Preterm and Term Delivery. \textit{Disease Markers}. London: Hindawi Publishing Corporation, 2018, vol.~2018, No~7628957, p.~1-9. ISSN~0278-0240. Available from: https://dx.doi.org/10.1155/2018/7628957.
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