J 2018

Vulvar cancer recurrence - an analysis of prognostic factors in tumour-free pathological margins patients group

MINÁŘ, Luboš, Michal FELSINGER, Marta ČÍHALOVÁ, Filip ZLÁMAL, Julie BIENERTOVÁ VAŠKŮ et. al.

Basic information

Original name

Vulvar cancer recurrence - an analysis of prognostic factors in tumour-free pathological margins patients group

Authors

MINÁŘ, Luboš (203 Czech Republic, guarantor, belonging to the institution), Michal FELSINGER (203 Czech Republic, belonging to the institution), Marta ČÍHALOVÁ (203 Czech Republic), Filip ZLÁMAL (203 Czech Republic, belonging to the institution) and Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution)

Edition

GINEKOLOGIA POLSKA, GDANSK, VIA MEDICA, 2018, 0017-0011

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30214 Obstetrics and gynaecology

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.747

RIV identification code

RIV/00216224:14110/18:00104063

Organization unit

Faculty of Medicine

DOI

UT WoS

000444810900004

Keywords in English

squamous cell vulvar cancer; surgical treatment; tumour-free pathological margins; local recurrence

Tags

Tags

International impact, Reviewed
Změněno: 26/3/2019 10:41, Soňa Böhmová

Abstract

V originále

Objectives:To evaluate risk factors associated with the local recurrence of invasive squamous cell vulvar cancer in patient group with tumor-free pathological margins. Material and methods: This is a retrospective analysis of 47 patients who underwent surgical treatment at University Hospital Brno, the Czech Republic between 2007 and 2014. 24 patients were classified as IB stage and three as II stage. A further 20 patients representing stage III showed the metastatic involvement of regional lymph nodes. Seven prognostic factors were analyzed in relation to local tumour recurrence: tumour size, margin distance, depth of invasion, lymphovascular space involvement (LVSI), midline involvement, metastatic lymph nodes and FIGO stage. Results: All prognostic factors were found to be statistically significant with respect to the risk of local recurrence. The highest risk of local recurrence was observed for the depth of invasion > 5 mm (HR, 12.42 [95% CI; 3.44-44.841) and for the presence of LVSI (HR, 10.83 [95% CI; 3.87-30.28]).The study also established a clear difference in the risk of local recurrence between patient groups with resection margin < 8 vs. >= 8 mm (HR, 4.91 [95% CI; 1.73-13.93; p = 0.003]. Conclusions: Tumour-free pathological margin of >= 8 mm is a major prognostic factor of local recurrence which can be influenced by the surgeon. A perfect knowledge of the extent of the disease prior to surgery supports adequately radical surgical trends. The emphasis is given on adequate radicality as well as on the reduction of overtreatment without worsening prognosis by simultaneously preserving the quality of life.