The Role of Inflammatory Response in Stroke Associated
Programmed Cell Death

J 2018

The Role of Inflammatory Response in Stroke Associated Programmed Cell Death

ĎURIŠ, Kamil, Zbyněk ŠPLÍCHAL and Michal JURAJDA

Basic information

Original name

The Role of Inflammatory Response in Stroke Associated Programmed Cell Death

Authors

ĎURIŠ, Kamil (203 Czech Republic, belonging to the institution), Zbyněk ŠPLÍCHAL (203 Czech Republic, belonging to the institution) and Michal JURAJDA (203 Czech Republic, guarantor, belonging to the institution)

Edition

CURRENT NEUROPHARMACOLOGY, SHARJAH, BENTHAM SCIENCE PUBL LTD, 2018, 1570-159X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Arab Emirates

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.568

RIV identification code

RIV/00216224:14110/18:00101264

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.2174/1570159X16666180222155833

UT WoS

000446492500013

Keywords in English

Inflammation; stroke; necrosis; apoptosis; necroptosis; pyroptosis; autophagy

Abstract

V originále

Stroke represents devastating pathology which is associated with a high morbidity and mortality. Initial damage caused directly by the onset of stroke, primary injury, may be eclipsed by secondary injury which may have a much more devastating effect on the brain. Primary injury is predominantly associated with necrotic cell death due to fatal insufficiency of oxygen and glucose. Secondary injury may on the contrary, lead apoptotic cell death due to structural damage which is not compatible with cellular functions or which may even represent the danger of malign transformation. The immune system is responsible for surveillance, defense and healing processes and the immune system plays a major role in triggering programmed cell death. Severe pathologies, such as stroke, are often associated with deregulation of the immune system, resulting in aggravation of secondary brain injury. The goal of this article is to overview the current knowledge about the role of immune system in the pathophysiology of stroke with respect to programmed neuronal cell death as well as to discuss current therapeutic strategies targeting inflammation after stroke.

Links

GP14-23773P, research and development project

Name: Regulace zánětlivé odpovědi prostřednictvím mikroRNA na experimaentálním modelu subarachnoidálního krvácení

Investor: Czech Science Foundation

Citovat

ĎURIŠ, Kamil, Zbyněk ŠPLÍCHAL and Michal JURAJDA. The Role of Inflammatory Response in Stroke Associated Programmed Cell Death. CURRENT NEUROPHARMACOLOGY. SHARJAH: BENTHAM SCIENCE PUBL LTD, 2018, vol. 16, No 9, p. 1365-1374. ISSN 1570-159X. Available from: https://dx.doi.org/10.2174/1570159X16666180222155833.

@article{1450476,
   author = {Ďuriš, Kamil and Šplíchal, Zbyněk and Jurajda, Michal},
   article_location = {SHARJAH},
   article_number = {9},
   doi = {http://dx.doi.org/10.2174/1570159X16666180222155833},
   keywords = {Inflammation; stroke; necrosis; apoptosis; necroptosis; pyroptosis; autophagy},
   language = {eng},
   issn = {1570-159X},
   journal = {CURRENT NEUROPHARMACOLOGY},
   title = {The Role of Inflammatory Response in Stroke Associated Programmed Cell Death},
   volume = {16},
   year = {2018}
}

TY  - JOUR
ID  - 1450476
AU  - Ďuriš, Kamil - Šplíchal, Zbyněk - Jurajda, Michal
PY  - 2018
TI  - The Role of Inflammatory Response in Stroke Associated Programmed Cell Death
JF  - CURRENT NEUROPHARMACOLOGY
VL  - 16
IS  - 9
SP  - 1365-1374
EP  - 1365-1374
PB  - BENTHAM SCIENCE PUBL LTD
SN  - 1570159X
KW  - Inflammation
KW  - stroke
KW  - necrosis
KW  - apoptosis
KW  - necroptosis
KW  - pyroptosis
KW  - autophagy
N2  - Stroke represents devastating pathology which is associated with a high morbidity and mortality. Initial damage caused directly by the onset of stroke, primary injury, may be eclipsed by secondary injury which may have a much more devastating effect on the brain. Primary injury is predominantly associated with necrotic cell death due to fatal insufficiency of oxygen and glucose. Secondary injury may on the contrary, lead apoptotic cell death due to structural damage which is not compatible with cellular functions or which may even represent the danger of malign transformation. The immune system is responsible for surveillance, defense and healing processes and the immune system plays a major role in triggering programmed cell death. Severe pathologies, such as stroke, are often associated with deregulation of the immune system, resulting in aggravation of secondary brain injury. The goal of this article is to overview the current knowledge about the role of immune system in the pathophysiology of stroke with respect to programmed neuronal cell death as well as to discuss current therapeutic strategies targeting inflammation after stroke.
ER  -

ĎURIŠ, Kamil, Zbyněk ŠPLÍCHAL and Michal JURAJDA. The Role of Inflammatory Response in Stroke Associated Programmed Cell Death. \textit{CURRENT NEUROPHARMACOLOGY}. SHARJAH: BENTHAM SCIENCE PUBL LTD, 2018, vol.~16, No~9, p.~1365-1374. ISSN~1570-159X. Available from: https://dx.doi.org/10.2174/1570159X16666180222155833.

Detailed Information on Publication Record