| VINDIS, David, Martin HUTYRA, Daniel SANAK, Michal KRAL, Eva CECHAKOVA, Simona LITTNEROVÁ, Tomas ADAM, Jan PRECEK, Stepan HUDEC, Marketa JECMENOVA and Milos TABORSKY. Patent Foramen Ovale and the Risk of Cerebral Infarcts in Acute Pulmonary Embolism-A Prospective Observational Study. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES. AMSTERDAM: ELSEVIER SCIENCE BV, 2018, vol. 27, No 2, p. 357-364. ISSN 1052-3057. Available from: https://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2017.09.004. |
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@article{1450596,
author = {Vindis, David and Hutyra, Martin and Sanak, Daniel and Kral, Michal and Cechakova, Eva and Littnerová, Simona and Adam, Tomas and Precek, Jan and Hudec, Stepan and Jecmenova, Marketa and Taborsky, Milos},
article_location = {AMSTERDAM},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2017.09.004},
keywords = {Pulmonary embolism; patent foramen ovale; brain infarction; echocardiography; brain magnetic resonance imaging},
language = {eng},
issn = {1052-3057},
journal = {JOURNAL OF STROKE & CEREBROVASCULAR DISEASES},
title = {Patent Foramen Ovale and the Risk of Cerebral Infarcts in Acute Pulmonary Embolism-A Prospective Observational Study},
volume = {27},
year = {2018}
}
TY - JOUR
ID - 1450596
AU - Vindis, David - Hutyra, Martin - Sanak, Daniel - Kral, Michal - Cechakova, Eva - Littnerová, Simona - Adam, Tomas - Precek, Jan - Hudec, Stepan - Jecmenova, Marketa - Taborsky, Milos
PY - 2018
TI - Patent Foramen Ovale and the Risk of Cerebral Infarcts in Acute Pulmonary Embolism-A Prospective Observational Study
JF - JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
VL - 27
IS - 2
SP - 357-364
EP - 357-364
PB - ELSEVIER SCIENCE BV
SN - 10523057
KW - Pulmonary embolism
KW - patent foramen ovale
KW - brain infarction
KW - echocardiography
KW - brain magnetic resonance imaging
N2 - Background: Pulmonary embolism (PE) is associated with a risk of consecutive paradoxical embolism with brain infarction through a patent foramen ovale (PFO). The aims of this study were to assess the rate of new ischemic brain lesions (IBLs) using magnetic resonance imaging (MRI) during a 12-month follow-up period with anticoagulation and to evaluate the potential relationship with the presence of PFO on transesophageal echocardiography (TEE). Subjects and Methods: Seventy-eight patients with acute PE underwent baseline contrast TEE with brain MRI. After the 12-month follow-up, 58 underwent brain MRI. The rates of MRI documenting new IBLs were measured based on the presence of PFO. Results: PFO was detected in 31 patients (39.7%). At baseline MRI, IBL was present in 39 of 78 patients (50%). The presence of IBL was not significantly higher in patients with PFO than in patients without PFO (20 [64.5% patients with PFO] versus 19 [40.4% without PFO] of 39 patients with baseline IBL, P = .063). At the follow-up MRI, in the group with new IBL (9 of 58 patients, 15.5%), the number of patients with PFO was significantly higher than that without PFO (7 [33.3%] versus 2 [5.4%], P = .008). PFO was identified as an independent predictor of new IBL (odds ratio 4.6 [1.6-47.4], P = .008). Conclusions: The presence of PFO was associated with new IBL in patients with PE. These patients are at a higher risk of ischemic stroke despite effective anticoagulation therapy.
ER -
VINDIS, David, Martin HUTYRA, Daniel SANAK, Michal KRAL, Eva CECHAKOVA, Simona LITTNEROVÁ, Tomas ADAM, Jan PRECEK, Stepan HUDEC, Marketa JECMENOVA and Milos TABORSKY. Patent Foramen Ovale and the Risk of Cerebral Infarcts in Acute Pulmonary Embolism-A Prospective Observational Study. \textit{JOURNAL OF STROKE \&{}amp; CEREBROVASCULAR DISEASES}. AMSTERDAM: ELSEVIER SCIENCE BV, 2018, vol.~27, No~2, p.~357-364. ISSN~1052-3057. Available from: https://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2017.09.004.
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