Autoři
HOVANEC, Jan (276 Německo), Jack SIEMIATYCKI (124 Kanada), David I. CONWAY (826 Velká Británie a Severní Irsko), Ann OLSSON (250 Francie), Isabele STUCKER (250 Francie), Florence GUIDA (250 Francie), Karl-Heinz JOCKEL (276 Německo), Hermann POHLABELN (276 Německo), Wolfgang AHRENS (276 Německo), Irene BRUSKE (276 Německo), Heinz-Erich WICHMANN (276 Německo), Per GUSTAVSSON (752 Švédsko), Dario CONSONNI (380 Itálie), Franco MERLETTI (380 Itálie), Lorenzo RICHIARDI (380 Itálie), Lorenzo SIMONATO (380 Itálie), Cristina FORTES (380 Itálie), Marie-Elise PARENT (124 Kanada), John MCLAUGHLIN (124 Kanada), Paul DEMERS (124 Kanada), Maria Teresa LANDI (840 Spojené státy), Neil CAPORASO (840 Spojené státy), Adonina TARDON (724 Španělsko), David ZARIDZE (643 Rusko), Neonila SZESZENIA-DABROWSKA (616 Polsko), Peter RUDNAI (348 Maďarsko), Jolanta LISSOWSKA (616 Polsko), Eleonora FABIANOVA (703 Slovensko), John FIELD (642 Rumunsko), Rodica Stanescu DUMITRU (642 Rumunsko), Vladimir BENCKO (203 Česká republika), Lenka FORETOVÁ (203 Česká republika, domácí), Vladimir JANOUT (203 Česká republika), Hans KROMHOUT (528 Nizozemské království), Roel VERMEULEN (528 Nizozemské království), Paolo BOFFETTA (840 Spojené státy), Kurt STRAIF (250 Francie), Joachim SCHUZ (250 Francie), Benjamin KENDZIA (276 Německo), Beate PESCH (276 Německo), Thomas BRUNING (276 Německo) a Thomas BEHRENS (276 Německo, garant)
Vydání
Plos one, San Francisco, Public Library Science, 2018, 1932-6203
V originále
Background An association between low socioeconomic status (SES) and lung cancer has been observed in several studies, but often without adequate control for smoking behavior. We studied the association between lung cancer and occupationally derived SES, using data from the international pooled SYNERGY study. Methods Twelve case-control studies from Europe and Canada were included in the analysis. Based on occupational histories of study participants we measured SES using the International Socio-Economic Index of Occupational Status (ISEI) and the European Socio-economic Classification (ESeC). We divided the ISEI range into categories, using various criteria. Stratifying by gender, we calculated odds ratios (OR) and 95% confidence intervals (CI) by unconditional logistic regression, adjusting for age, study, and smoking behavior. We conducted analyses by histological subtypes of lung cancer and subgroup analyses by study region, birth cohort, education and occupational exposure to known lung carcinogens. Results The analysis dataset included 17,021 cases and 20,885 controls. There was a strong elevated OR between lung cancer and low SES, which was attenuated substantially after adjustment for smoking, however a social gradient persisted. SES differences in lung cancer risk were higher among men (lowest vs. highest SES category: ISEI OR 1.84 (95% CI 1.61-2.09); ESeC OR 1.53 (95% CI 1.44-1.63)), than among women (lowest vs. highest SES category: ISEI OR 1.54 (95% CI 1.20-1.98); ESeC OR 1.34 (95% CI 1.19-1.52)). Conclusion SES remained a risk factor for lung cancer after adjustment for smoking behavior.