Early Dynamics of Interleukin-6 in Cerebrospinal Fluid after
Aneurysmal Subarachnoid Hemorrhage

J 2018

Early Dynamics of Interleukin-6 in Cerebrospinal Fluid after Aneurysmal Subarachnoid Hemorrhage

ĎURIŠ, Kamil, Eduard NEUMAN, Václav VYBÍHAL, Vilém JURÁŇ, Jana GOTTWALDOVÁ et. al.

Basic information

Original name

Early Dynamics of Interleukin-6 in Cerebrospinal Fluid after Aneurysmal Subarachnoid Hemorrhage

Authors

ĎURIŠ, Kamil (203 Czech Republic, belonging to the institution), Eduard NEUMAN (203 Czech Republic, belonging to the institution), Václav VYBÍHAL (203 Czech Republic, belonging to the institution), Vilém JURÁŇ (203 Czech Republic, belonging to the institution), Jana GOTTWALDOVÁ (203 Czech Republic, belonging to the institution), Michal KÝR (203 Czech Republic, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, belonging to the institution) and Martin SMRČKA (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Neurological Surgery, Part A: Central European Neurosurgery, New York, Thieme Medical Publ Inc, 2018, 2193-6315

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.060

RIV identification code

RIV/00216224:14110/18:00104086

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1055/s-0037-1604084

UT WoS

000426299500007

Keywords in English

subarachnoid hemorrhage; early brain injury; inflammation; IL-6

Abstract

V originále

Background Subarachnoid hemorrhage (SAH) is a severe condition associated with high mortality. Early brain injury (EBI) plays an important role in the pathophysiology of SAH, and inflammation is a major contributor to EBI. Inflammation is a widely studied topic in both experimental and clinical conditions; however, just a few clinical studies have focused primarily on the early inflammatory response after SAH, and detailed information about the association between the dynamics of early inflammatory response with main clinical characteristics is lacking. This study analyzes the early dynamics of inflammatory response after SAH and evaluates the possible associations between the markers of early inflammatory response and main clinical characteristics. Patients and Methods A total of 47 patients with a diagnosis of aneurysmal SAH within the last 24 hours were enrolled in the study. All treatments, including treatment of aneurysm (surgery/coiling) and implantation of a drainage system (external ventricular drainage/lumbar catheter), were conducted in the same way as in other patients with this diagnosis. Blood and cerebrospinal fluid (CSF) samples were collected three times a day for 4 days. The dynamics of proinflammatory cytokines were assessed, and associations between levels of the proinflammatory cytokines interleukin (IL)-6, IL-1, or tumor necrosis factor (TNF) and main clinical characteristics were evaluated using linear mixed-effect models. Results The CSF levels of IL-6 were massively increased initially after SAH (up to 72 hours) with an additional increase in later phases (after 72 hours), but there was high variability in IL-6 levels. A significant association was noted between the Glasgow Outcome Scale score and both overall levels of IL-6 ( p =0.0095) and their dynamics ( p =0.0208); the effect of the Hunt and Hess scale was borderline ( p =0.0887). No association was found between IL-6 levels and Fisher grade, modality of treatment (surgery, coiling, no treatment), and later development of cerebral vasospasm. Plasmatic levels of IL-6 increased slightly, but no significant association was found. The levels of IL-1 and TNF were within the physiologic range in both CSF and plasma. Conclusions Early dynamics of IL-6 in CSF are associated with a patient's outcome. But it is difficult to use IL-6 alone for outcome prediction due to its high variability. The question is whether the dynamics of IL-6 could be used in combination with other early markers associated with brain injury. More detailed research is required to answer this question.

Citovat

ĎURIŠ, Kamil, Eduard NEUMAN, Václav VYBÍHAL, Vilém JURÁŇ, Jana GOTTWALDOVÁ, Michal KÝR, Anna VAŠKŮ and Martin SMRČKA. Early Dynamics of Interleukin-6 in Cerebrospinal Fluid after Aneurysmal Subarachnoid Hemorrhage. Journal of Neurological Surgery, Part A: Central European Neurosurgery. New York: Thieme Medical Publ Inc, 2018, vol. 79, No 2, p. 145-151. ISSN 2193-6315. Available from: https://dx.doi.org/10.1055/s-0037-1604084.

@article{1451441,
   author = {Ďuriš, Kamil and Neuman, Eduard and Vybíhal, Václav and Juráň, Vilém and Gottwaldová, Jana and Kýr, Michal and Vašků, Anna and Smrčka, Martin},
   article_location = {New York},
   article_number = {2},
   doi = {http://dx.doi.org/10.1055/s-0037-1604084},
   keywords = {subarachnoid hemorrhage; early brain injury; inflammation; IL-6},
   language = {eng},
   issn = {2193-6315},
   journal = {Journal of Neurological Surgery, Part A: Central European Neurosurgery},
   title = {Early Dynamics of Interleukin-6 in Cerebrospinal Fluid after Aneurysmal Subarachnoid Hemorrhage},
   volume = {79},
   year = {2018}
}

TY  - JOUR
ID  - 1451441
AU  - Ďuriš, Kamil - Neuman, Eduard - Vybíhal, Václav - Juráň, Vilém - Gottwaldová, Jana - Kýr, Michal - Vašků, Anna - Smrčka, Martin
PY  - 2018
TI  - Early Dynamics of Interleukin-6 in Cerebrospinal Fluid after Aneurysmal Subarachnoid Hemorrhage
JF  - Journal of Neurological Surgery, Part A: Central European Neurosurgery
VL  - 79
IS  - 2
SP  - 145-151
EP  - 145-151
PB  - Thieme Medical Publ Inc
SN  - 21936315
KW  - subarachnoid hemorrhage
KW  - early brain injury
KW  - inflammation
KW  - IL-6
N2  - Background Subarachnoid hemorrhage (SAH) is a severe condition associated with high mortality. Early brain injury (EBI) plays an important role in the pathophysiology of SAH, and inflammation is a major contributor to EBI. Inflammation is a widely studied topic in both experimental and clinical conditions; however, just a few clinical studies have focused primarily on the early inflammatory response after SAH, and detailed information about the association between the dynamics of early inflammatory response with main clinical characteristics is lacking. This study analyzes the early dynamics of inflammatory response after SAH and evaluates the possible associations between the markers of early inflammatory response and main clinical characteristics. Patients and Methods A total of 47 patients with a diagnosis of aneurysmal SAH within the last 24 hours were enrolled in the study. All treatments, including treatment of aneurysm (surgery/coiling) and implantation of a drainage system (external ventricular drainage/lumbar catheter), were conducted in the same way as in other patients with this diagnosis. Blood and cerebrospinal fluid (CSF) samples were collected three times a day for 4 days. The dynamics of proinflammatory cytokines were assessed, and associations between levels of the proinflammatory cytokines interleukin (IL)-6, IL-1, or tumor necrosis factor (TNF) and main clinical characteristics were evaluated using linear mixed-effect models. Results The CSF levels of IL-6 were massively increased initially after SAH (up to 72 hours) with an additional increase in later phases (after 72 hours), but there was high variability in IL-6 levels. A significant association was noted between the Glasgow Outcome Scale score and both overall levels of IL-6 ( p =0.0095) and their dynamics ( p =0.0208); the effect of the Hunt and Hess scale was borderline ( p =0.0887). No association was found between IL-6 levels and Fisher grade, modality of treatment (surgery, coiling, no treatment), and later development of cerebral vasospasm. Plasmatic levels of IL-6 increased slightly, but no significant association was found. The levels of IL-1 and TNF were within the physiologic range in both CSF and plasma. Conclusions Early dynamics of IL-6 in CSF are associated with a patient's outcome. But it is difficult to use IL-6 alone for outcome prediction due to its high variability. The question is whether the dynamics of IL-6 could be used in combination with other early markers associated with brain injury. More detailed research is required to answer this question.
ER  -

ĎURIŠ, Kamil, Eduard NEUMAN, Václav VYBÍHAL, Vilém JURÁŇ, Jana GOTTWALDOVÁ, Michal KÝR, Anna VAŠKŮ and Martin SMRČKA. Early Dynamics of Interleukin-6 in Cerebrospinal Fluid after Aneurysmal Subarachnoid Hemorrhage. \textit{Journal of Neurological Surgery, Part A: Central European Neurosurgery}. New York: Thieme Medical Publ Inc, 2018, vol.~79, No~2, p.~145-151. ISSN~2193-6315. Available from: https://dx.doi.org/10.1055/s-0037-1604084.

Detailed Information on Publication Record