Genetic Contributions to The Association Between Adult Height
and Head and Neck Cancer: A Mendelian Randomization Analysis

J 2018

Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis

PASTORINO, Roberta, Anna PUGGINA, Robert CARRERAS-TORRES, Pagona LAGIOU, Ivana HOLCATOVA et. al.

Basic information

Original name

Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis

Authors

PASTORINO, Roberta (380 Italy), Anna PUGGINA (380 Italy, guarantor), Robert CARRERAS-TORRES (250 France), Pagona LAGIOU (300 Greece), Ivana HOLCATOVA (203 Czech Republic), Lorenzo RICHIARDI (380 Italy), Kristina KJAERHEIM (578 Norway), Antonio AGUDO (724 Spain), Xavier CASTELLSAGUE (724 Spain), Tatiana V. MACFARLANE (826 United Kingdom of Great Britain and Northern Ireland), Luigi BARZAN (380 Italy), Cristina CANOVA (380 Italy), Nalin S. THAKKER (826 United Kingdom of Great Britain and Northern Ireland), David I. CONWAY (826 United Kingdom of Great Britain and Northern Ireland), Ariana ZNAOR (191 Croatia), Claire M. HEALY (372 Ireland), Wolfgang AHRENS (276 Germany), David ZARIDZE (643 Russian Federation), Neonilia SZESZENIA-DABROWSKA (616 Poland), Jolanta LISSOWSKA (616 Poland), Eleonora FABIANOVA (703 Slovakia), Ioan Nicolae MATES (642 Romania), Vladimír BENCKO (203 Czech Republic, belonging to the institution), Lenka FORETOVÁ (203 Czech Republic, belonging to the institution), Vladimir JANOUT (203 Czech Republic), Paul BRENNAN (250 France), Valerie GABORIEAU (250 France), James D. MCKAY (250 France) and Stefania BOCCIA (380 Italy)

Edition

Scientific reports, LONDON, NATURE PUBLISHING GROUP, 2018, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.011

RIV identification code

RIV/00216224:14110/18:00104090

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/s41598-018-22626-w

UT WoS

000427366200064

Keywords in English

head and neck cancer

Abstract

V originále

With the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association between genetic instruments for height and the risk of HNC. 599 single nucleotide polymorphisms (SNPs) were identified as genetic instruments for height, accounting for 16% of the phenotypic variation. Genetic data concerning HNC cases and controls were obtained from a genome-wide association study. Summary statistics for genetic association were used in complementary MR approaches: the weighted genetic risk score (GRS) and the inverse-variance weighted (IVW). MR-Egger regression was used for sensitivity analysis and pleiotropy evaluation. From the GRS analysis, one standard deviation (SD) higher height (6.9 cm; due to genetic predisposition across 599 SNPs) raised the risk for HNC (Odds ratio (OR), 1.14; 95% Confidence Interval (95% CI), 0.99-1.32). The association analyses with potential confounders revealed that the GRS was associated with tobacco smoking (OR = 0.80, 95% CI (0.69-0.93)). MR-Egger regression did not provide evidence of overall directional pleiotropy. Our study indicates that height is potentially associated with HNC risk. However, the reported risk could be underestimated since, at the genetic level, height emerged to be inversely associated with smoking.

Citovat

PASTORINO, Roberta, Anna PUGGINA, Robert CARRERAS-TORRES, Pagona LAGIOU, Ivana HOLCATOVA, Lorenzo RICHIARDI, Kristina KJAERHEIM, Antonio AGUDO, Xavier CASTELLSAGUE, Tatiana V. MACFARLANE, Luigi BARZAN, Cristina CANOVA, Nalin S. THAKKER, David I. CONWAY, Ariana ZNAOR, Claire M. HEALY, Wolfgang AHRENS, David ZARIDZE, Neonilia SZESZENIA-DABROWSKA, Jolanta LISSOWSKA, Eleonora FABIANOVA, Ioan Nicolae MATES, Vladimír BENCKO, Lenka FORETOVÁ, Vladimir JANOUT, Paul BRENNAN, Valerie GABORIEAU, James D. MCKAY and Stefania BOCCIA. Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2018, vol. 8, No 4534, p. 1-6. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-018-22626-w.

@article{1451517,
   author = {Pastorino, Roberta and Puggina, Anna and CarrerasandTorres, Robert and Lagiou, Pagona and Holcatova, Ivana and Richiardi, Lorenzo and Kjaerheim, Kristina and Agudo, Antonio and Castellsague, Xavier and Macfarlane, Tatiana V. and Barzan, Luigi and Canova, Cristina and Thakker, Nalin S. and Conway, David I. and Znaor, Ariana and Healy, Claire M. and Ahrens, Wolfgang and Zaridze, David and SzeszeniaandDabrowska, Neonilia and Lissowska, Jolanta and Fabianova, Eleonora and Mates, Ioan Nicolae and Bencko, Vladimír and Foretová, Lenka and Janout, Vladimir and Brennan, Paul and Gaborieau, Valerie and Mckay, James D. and Boccia, Stefania},
   article_location = {LONDON},
   article_number = {4534},
   doi = {http://dx.doi.org/10.1038/s41598-018-22626-w},
   keywords = {head and neck cancer},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific reports},
   title = {Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis},
   volume = {8},
   year = {2018}
}

TY  - JOUR
ID  - 1451517
AU  - Pastorino, Roberta - Puggina, Anna - Carreras-Torres, Robert - Lagiou, Pagona - Holcatova, Ivana - Richiardi, Lorenzo - Kjaerheim, Kristina - Agudo, Antonio - Castellsague, Xavier - Macfarlane, Tatiana V. - Barzan, Luigi - Canova, Cristina - Thakker, Nalin S. - Conway, David I. - Znaor, Ariana - Healy, Claire M. - Ahrens, Wolfgang - Zaridze, David - Szeszenia-Dabrowska, Neonilia - Lissowska, Jolanta - Fabianova, Eleonora - Mates, Ioan Nicolae - Bencko, Vladimír - Foretová, Lenka - Janout, Vladimir - Brennan, Paul - Gaborieau, Valerie - Mckay, James D. - Boccia, Stefania
PY  - 2018
TI  - Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis
JF  - Scientific reports
VL  - 8
IS  - 4534
SP  - 1-6
EP  - 1-6
PB  - NATURE PUBLISHING GROUP
SN  - 20452322
KW  - head and neck cancer
N2  - With the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association between genetic instruments for height and the risk of HNC. 599 single nucleotide polymorphisms (SNPs) were identified as genetic instruments for height, accounting for 16% of the phenotypic variation. Genetic data concerning HNC cases and controls were obtained from a genome-wide association study. Summary statistics for genetic association were used in complementary MR approaches: the weighted genetic risk score (GRS) and the inverse-variance weighted (IVW). MR-Egger regression was used for sensitivity analysis and pleiotropy evaluation. From the GRS analysis, one standard deviation (SD) higher height (6.9 cm; due to genetic predisposition across 599 SNPs) raised the risk for HNC (Odds ratio (OR), 1.14; 95% Confidence Interval (95% CI), 0.99-1.32). The association analyses with potential confounders revealed that the GRS was associated with tobacco smoking (OR = 0.80, 95% CI (0.69-0.93)). MR-Egger regression did not provide evidence of overall directional pleiotropy. Our study indicates that height is potentially associated with HNC risk. However, the reported risk could be underestimated since, at the genetic level, height emerged to be inversely associated with smoking.
ER  -

PASTORINO, Roberta, Anna PUGGINA, Robert CARRERAS-TORRES, Pagona LAGIOU, Ivana HOLCATOVA, Lorenzo RICHIARDI, Kristina KJAERHEIM, Antonio AGUDO, Xavier CASTELLSAGUE, Tatiana V. MACFARLANE, Luigi BARZAN, Cristina CANOVA, Nalin S. THAKKER, David I. CONWAY, Ariana ZNAOR, Claire M. HEALY, Wolfgang AHRENS, David ZARIDZE, Neonilia SZESZENIA-DABROWSKA, Jolanta LISSOWSKA, Eleonora FABIANOVA, Ioan Nicolae MATES, Vladimír BENCKO, Lenka FORETOVÁ, Vladimir JANOUT, Paul BRENNAN, Valerie GABORIEAU, James D. MCKAY and Stefania BOCCIA. Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis. \textit{Scientific reports}. LONDON: NATURE PUBLISHING GROUP, 2018, vol.~8, No~4534, p.~1-6. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-018-22626-w.

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