BEŇOVSKÁ, Miroslava, Aneta OPLUŠTILOVÁ, Jana PINKAVOVÁ, Zuzana HODICKÁ and Zdeňka ČERMÁKOVÁ. The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation. LABORATORY MEDICINE. OXFORD: OXFORD UNIV PRESS, 2018, vol. 49, No 2, p. 112-117. ISSN 0007-5027. Available from: https://dx.doi.org/10.1093/labmed/lmx076.
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Basic information
Original name The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation
Authors BEŇOVSKÁ, Miroslava (203 Czech Republic, guarantor, belonging to the institution), Aneta OPLUŠTILOVÁ (203 Czech Republic), Jana PINKAVOVÁ (203 Czech Republic), Zuzana HODICKÁ (203 Czech Republic, belonging to the institution) and Zdeňka ČERMÁKOVÁ (203 Czech Republic, belonging to the institution).
Edition LABORATORY MEDICINE, OXFORD, OXFORD UNIV PRESS, 2018, 0007-5027.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 20602 Medical laboratory technology ;
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.020
RIV identification code RIV/00216224:14110/18:00104136
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1093/labmed/lmx076
UT WoS 000435092600006
Keywords in English preeclampsia; angiogenic factors; placental growth factor; sFlt-1; PIGF; sFlt-1/PIGF ratio
Tags 14110411, 14110616, rivok
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 11/2/2019 14:14.
Abstract
Background: Soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PIGF) ate used in diagnosing preeclampsia (PE), but their potential in early prediction in pregnant women at 16 to 20 weeks gestation (WG) has remained unexplored. Methods: We retrospectively measured serum levels of sFlt-1 and PIGF in 120 pregnant women at 16 to 20 WG. Among these women, 16 had early-onset PE and 23 had late-onset PE. Results: Compared with normal pregnancy values, in the serum of women in whom PE later developed, sFlt-1 values increased (P <.001), values of PIGF decreased (P = .001), and the sFlt-1/PIGF ratio increased (P <.001) as early as 16 to 20 WG. Receiver operating characteristic (ROC) curve analysis for the sFlt-1/PIGF ratio at 16 to 20 WG showed an area under the curve (AUC) value of 0.863 (95% confidence interval [CI], 0.788-0.918), P <.001, sensitivity of 74.4%, and specificity of 86.6 degrees k for PE in general; and AUC of 0.970 (95% CI, 0.913-0.994), P <.001, sensitivity of 100%, and specificity of 81.5% for early-onset PE only. Also, we determined the 5th and 95th percentiles for sFlt-1, PIGF, and sFlt-1/PIGF ratio values of healthy pregnant women. Conclusion: sFlt-1 and PIGF and, in particular, the sFlt-1/PIGF ratio can detect PE as early as 16 to 20 WG-as long as 10 to 15 weeks before PE onset.
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