The New Possibilities in Early Diagnosis of Preeclampsia by
Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor
in 16-20 Weeks Gestation

J 2018

The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation

BEŇOVSKÁ, Miroslava, Aneta OPLUŠTILOVÁ, Jana PINKAVOVÁ, Zuzana HODICKÁ, Zdeňka ČERMÁKOVÁ et. al.

Basic information

Original name

The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation

Authors

BEŇOVSKÁ, Miroslava (203 Czech Republic, guarantor, belonging to the institution), Aneta OPLUŠTILOVÁ (203 Czech Republic), Jana PINKAVOVÁ (203 Czech Republic), Zuzana HODICKÁ (203 Czech Republic, belonging to the institution) and Zdeňka ČERMÁKOVÁ (203 Czech Republic, belonging to the institution)

Edition

LABORATORY MEDICINE, OXFORD, OXFORD UNIV PRESS, 2018, 0007-5027

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

20602 Medical laboratory technology ;

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.020

RIV identification code

RIV/00216224:14110/18:00104136

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1093/labmed/lmx076

UT WoS

000435092600006

Keywords in English

preeclampsia; angiogenic factors; placental growth factor; sFlt-1; PIGF; sFlt-1/PIGF ratio

Abstract

V originále

Background: Soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PIGF) ate used in diagnosing preeclampsia (PE), but their potential in early prediction in pregnant women at 16 to 20 weeks gestation (WG) has remained unexplored. Methods: We retrospectively measured serum levels of sFlt-1 and PIGF in 120 pregnant women at 16 to 20 WG. Among these women, 16 had early-onset PE and 23 had late-onset PE. Results: Compared with normal pregnancy values, in the serum of women in whom PE later developed, sFlt-1 values increased (P <.001), values of PIGF decreased (P = .001), and the sFlt-1/PIGF ratio increased (P <.001) as early as 16 to 20 WG. Receiver operating characteristic (ROC) curve analysis for the sFlt-1/PIGF ratio at 16 to 20 WG showed an area under the curve (AUC) value of 0.863 (95% confidence interval [CI], 0.788-0.918), P <.001, sensitivity of 74.4%, and specificity of 86.6 degrees k for PE in general; and AUC of 0.970 (95% CI, 0.913-0.994), P <.001, sensitivity of 100%, and specificity of 81.5% for early-onset PE only. Also, we determined the 5th and 95th percentiles for sFlt-1, PIGF, and sFlt-1/PIGF ratio values of healthy pregnant women. Conclusion: sFlt-1 and PIGF and, in particular, the sFlt-1/PIGF ratio can detect PE as early as 16 to 20 WG-as long as 10 to 15 weeks before PE onset.

Citovat

BEŇOVSKÁ, Miroslava, Aneta OPLUŠTILOVÁ, Jana PINKAVOVÁ, Zuzana HODICKÁ and Zdeňka ČERMÁKOVÁ. The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation. LABORATORY MEDICINE. OXFORD: OXFORD UNIV PRESS, 2018, vol. 49, No 2, p. 112-117. ISSN 0007-5027. Available from: https://dx.doi.org/10.1093/labmed/lmx076.

@article{1453558,
   author = {Beňovská, Miroslava and Opluštilová, Aneta and Pinkavová, Jana and Hodická, Zuzana and Čermáková, Zdeňka},
   article_location = {OXFORD},
   article_number = {2},
   doi = {http://dx.doi.org/10.1093/labmed/lmx076},
   keywords = {preeclampsia; angiogenic factors; placental growth factor; sFlt-1; PIGF; sFlt-1/PIGF ratio},
   language = {eng},
   issn = {0007-5027},
   journal = {LABORATORY MEDICINE},
   title = {The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation},
   volume = {49},
   year = {2018}
}

TY  - JOUR
ID  - 1453558
AU  - Beňovská, Miroslava - Opluštilová, Aneta - Pinkavová, Jana - Hodická, Zuzana - Čermáková, Zdeňka
PY  - 2018
TI  - The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation
JF  - LABORATORY MEDICINE
VL  - 49
IS  - 2
SP  - 112-117
EP  - 112-117
PB  - OXFORD UNIV PRESS
SN  - 00075027
KW  - preeclampsia
KW  - angiogenic factors
KW  - placental growth factor
KW  - sFlt-1
KW  - PIGF
KW  - sFlt-1/PIGF ratio
N2  - Background: Soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PIGF) ate used in diagnosing preeclampsia (PE), but their potential in early prediction in pregnant women at 16 to 20 weeks gestation (WG) has remained unexplored. Methods: We retrospectively measured serum levels of sFlt-1 and PIGF in 120 pregnant women at 16 to 20 WG. Among these women, 16 had early-onset PE and 23 had late-onset PE. Results: Compared with normal pregnancy values, in the serum of women in whom PE later developed, sFlt-1 values increased (P <.001), values of PIGF decreased (P = .001), and the sFlt-1/PIGF ratio increased (P <.001) as early as 16 to 20 WG. Receiver operating characteristic (ROC) curve analysis for the sFlt-1/PIGF ratio at 16 to 20 WG showed an area under the curve (AUC) value of 0.863 (95% confidence interval [CI], 0.788-0.918), P <.001, sensitivity of 74.4%, and specificity of 86.6 degrees k for PE in general; and AUC of 0.970 (95% CI, 0.913-0.994), P <.001, sensitivity of 100%, and specificity of 81.5% for early-onset PE only. Also, we determined the 5th and 95th percentiles for sFlt-1, PIGF, and sFlt-1/PIGF ratio values of healthy pregnant women. Conclusion: sFlt-1 and PIGF and, in particular, the sFlt-1/PIGF ratio can detect PE as early as 16 to 20 WG-as long as 10 to 15 weeks before PE onset.
ER  -

BEŇOVSKÁ, Miroslava, Aneta OPLUŠTILOVÁ, Jana PINKAVOVÁ, Zuzana HODICKÁ and Zdeňka ČERMÁKOVÁ. The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation. \textit{LABORATORY MEDICINE}. OXFORD: OXFORD UNIV PRESS, 2018, vol.~49, No~2, p.~112-117. ISSN~0007-5027. Available from: https://dx.doi.org/10.1093/labmed/lmx076.

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