J 2018

Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: The Kardiovize Study

HRUSKOVA, Jana, Andrea MAUGERI, Helena PODROUŽKOVÁ, Tatiana ŠTÍPALOVÁ, Juraj JAKUBÍK et. al.

Basic information

Original name

Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: The Kardiovize Study

Authors

HRUSKOVA, Jana (203 Czech Republic), Andrea MAUGERI (203 Czech Republic), Helena PODROUŽKOVÁ (203 Czech Republic, belonging to the institution), Tatiana ŠTÍPALOVÁ (703 Slovakia, belonging to the institution), Juraj JAKUBÍK (703 Slovakia), Martina BARCHITTA (380 Italy), Jose R. MEDINA-INOJOSA (840 United States of America), Martin HOMOLKA (203 Czech Republic), Antonella AGODI (380 Italy), Šárka KUNZOVÁ (203 Czech Republic), Ondřej SOCHOR (203 Czech Republic), Francisco LOPEZ-JIMENEZ (840 United States of America) and Manlio VINCIGUERRA (380 Italy, guarantor)

Edition

JOURNAL OF CLINICAL MEDICINE, BASEL, MDPI, 2018, 2077-0383

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 5.688

RIV identification code

RIV/00216224:14110/18:00104138

Organization unit

Faculty of Medicine

UT WoS

000435194400026

Keywords in English

cardiovascular risk; epicardial adipose tissue; intima media thickness

Tags

Tags

International impact, Reviewed
Změněno: 22/10/2018 09:59, Soňa Böhmová

Abstract

V originále

Background: Intima-media thickness (IMT) has been proposed as a measurement of subclinical atherosclerosis and has been associated with cardiovascular disease (CVD). Epicardial adipose tissue (EAT) is a fat depot between the pericardium and myocardium and has been associated with coronary atherosclerosis. The relationship between IMT and EAT thickness has not been reported before. We investigated the relationship between EAT thickness, IMT, CVD risk factors, and ideal cardiovascular health (CVH) metrics using subjects from the Kardiovize Brno 2030 cohort study, a random urban sample population in Central Europe. Methods: We studied 102 individuals (65 males) aged 25-64 years (median = 37 years) with no current or past CVD history. We measured IMT using a vascular ultrasound and EAT thickness using transthoracic echocardiography, and collected data on anthropometric factors, CVD risk factors, and CVH score. Correlation tests and multiple linear regression models were applied. Results: In the age- and gender-adjusted model, we demonstrated that, among CVD risk factors, only BMI was significantly and positively associated with EAT thickness ( = 0.182, SE = 0.082, p = 0.030), while no significant associations with IMT were evident. Although both EAT thickness and IMT were negatively correlated with CVH score (r = -0.45, p < 0.001, and r = -0.38, p < 0.001, respectively), we demonstrated that overall CVH score (beta = -0.262; SE = 0.077; p = 0.001), as well as BMI (beta = -1.305; SE = 0.194; p < 0.001) and blood pressure CVH metrics (beta = -0.607; SE = 0.206; p = 0.004) were significantly associated with EAT thickness but not with IMT. Conclusions: Our study is important as it demonstrated for the first time that CVH is associated with EAT thickness. Interestingly, this relationship seems to be dependent on BMI and blood pressure rather than on the other CVH metrics. However, outcome-driven studies are required to confirm these findings.