HRUSKOVA, Jana, Andrea MAUGERI, Helena PODROUŽKOVÁ, Tatiana ŠTÍPALOVÁ, Juraj JAKUBÍK, Martina BARCHITTA, Jose R. MEDINA-INOJOSA, Martin HOMOLKA, Antonella AGODI, Šárka KUNZOVÁ, Ondřej SOCHOR, Francisco LOPEZ-JIMENEZ and Manlio VINCIGUERRA. Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: The Kardiovize Study. JOURNAL OF CLINICAL MEDICINE. BASEL: MDPI, 2018, vol. 7, No 5, p. 1-13. ISSN 2077-0383. Available from: https://dx.doi.org/10.3390/jcm7050113.
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Basic information
Original name Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: The Kardiovize Study
Authors HRUSKOVA, Jana (203 Czech Republic), Andrea MAUGERI (203 Czech Republic), Helena PODROUŽKOVÁ (203 Czech Republic, belonging to the institution), Tatiana ŠTÍPALOVÁ (703 Slovakia, belonging to the institution), Juraj JAKUBÍK (703 Slovakia), Martina BARCHITTA (380 Italy), Jose R. MEDINA-INOJOSA (840 United States of America), Martin HOMOLKA (203 Czech Republic), Antonella AGODI (380 Italy), Šárka KUNZOVÁ (203 Czech Republic), Ondřej SOCHOR (203 Czech Republic), Francisco LOPEZ-JIMENEZ (840 United States of America) and Manlio VINCIGUERRA (380 Italy, guarantor).
Edition JOURNAL OF CLINICAL MEDICINE, BASEL, MDPI, 2018, 2077-0383.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 5.688
RIV identification code RIV/00216224:14110/18:00104138
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.3390/jcm7050113
UT WoS 000435194400026
Keywords in English cardiovascular risk; epicardial adipose tissue; intima media thickness
Tags 14110115, rivok
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 22/10/2018 09:59.
Abstract
Background: Intima-media thickness (IMT) has been proposed as a measurement of subclinical atherosclerosis and has been associated with cardiovascular disease (CVD). Epicardial adipose tissue (EAT) is a fat depot between the pericardium and myocardium and has been associated with coronary atherosclerosis. The relationship between IMT and EAT thickness has not been reported before. We investigated the relationship between EAT thickness, IMT, CVD risk factors, and ideal cardiovascular health (CVH) metrics using subjects from the Kardiovize Brno 2030 cohort study, a random urban sample population in Central Europe. Methods: We studied 102 individuals (65 males) aged 25-64 years (median = 37 years) with no current or past CVD history. We measured IMT using a vascular ultrasound and EAT thickness using transthoracic echocardiography, and collected data on anthropometric factors, CVD risk factors, and CVH score. Correlation tests and multiple linear regression models were applied. Results: In the age- and gender-adjusted model, we demonstrated that, among CVD risk factors, only BMI was significantly and positively associated with EAT thickness ( = 0.182, SE = 0.082, p = 0.030), while no significant associations with IMT were evident. Although both EAT thickness and IMT were negatively correlated with CVH score (r = -0.45, p < 0.001, and r = -0.38, p < 0.001, respectively), we demonstrated that overall CVH score (beta = -0.262; SE = 0.077; p = 0.001), as well as BMI (beta = -1.305; SE = 0.194; p < 0.001) and blood pressure CVH metrics (beta = -0.607; SE = 0.206; p = 0.004) were significantly associated with EAT thickness but not with IMT. Conclusions: Our study is important as it demonstrated for the first time that CVH is associated with EAT thickness. Interestingly, this relationship seems to be dependent on BMI and blood pressure rather than on the other CVH metrics. However, outcome-driven studies are required to confirm these findings.
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