| DUBOVÝ, Petr, Ivana HRADILOVÁ SVÍŽENSKÁ, Ilona KLUSÁKOVÁ, Viktória KOKOŠOVÁ, Václav BRÁZDA and Marek JOUKAL. Bilateral activation of STAT3 by phosphorylation at the tyrosine-705 (Y705) and serine-727 (S727) positions and its nuclear translocation in primary sensory neurons following unilateral sciatic nerve injury. Histochemistry and Cell Biology. Heidelberg: Springer, 2018, vol. 150, No 1, p. 37-47. ISSN 0948-6143. Available from: https://dx.doi.org/10.1007/s00418-018-1656-y. |
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@article{1454516,
author = {Dubový, Petr and Hradilová Svíženská, Ivana and Klusáková, Ilona and Kokošová, Viktória and Brázda, Václav and Joukal, Marek},
article_location = {Heidelberg},
article_number = {1},
doi = {http://dx.doi.org/10.1007/s00418-018-1656-y},
keywords = {Dorsal root ganglia; Neuroinflammation; Systemic reaction; Peripheral nerve injury},
language = {eng},
issn = {0948-6143},
journal = {Histochemistry and Cell Biology},
title = {Bilateral activation of STAT3 by phosphorylation at the tyrosine-705 (Y705) and serine-727 (S727) positions and its nuclear translocation in primary sensory neurons following unilateral sciatic nerve injury},
volume = {150},
year = {2018}
}
TY - JOUR
ID - 1454516
AU - Dubový, Petr - Hradilová Svíženská, Ivana - Klusáková, Ilona - Kokošová, Viktória - Brázda, Václav - Joukal, Marek
PY - 2018
TI - Bilateral activation of STAT3 by phosphorylation at the tyrosine-705 (Y705) and serine-727 (S727) positions and its nuclear translocation in primary sensory neurons following unilateral sciatic nerve injury
JF - Histochemistry and Cell Biology
VL - 150
IS - 1
SP - 37-47
EP - 37-47
PB - Springer
SN - 09486143
KW - Dorsal root ganglia
KW - Neuroinflammation
KW - Systemic reaction
KW - Peripheral nerve injury
N2 - Unilateral sciatic nerve compression (SNC) or complete sciatic nerve transection (CSNT), both varying degrees of nerve injury, induced activation of STAT3 bilaterally in the dorsal root ganglia (DRG) neurons of lumbar (L4-L5) as well as cervical (C6-C8) spinal cord segments. STAT3 activation was by phosphorylation at the tyrosine-705 (Y705) and serine-727 (S727) positions and was followed by their nuclear translocation. This is the first evidence of STAT3(S727) activation together with the well-known activation of STAT3(Y705) in primary sensory neurons upon peripheral nerve injury. Bilateral activation of STAT3 in DRG neurons of spinal segments anatomically both associated as well as non-associated with the injured nerve indicates diffusion of STAT3 activation inducers along the spinal cord. Increased levels of IL-6 protein in the CSF following nerve injury as well as activation and nuclear translocation of STAT3 in DRG after intrathecal injection of IL-6 shows that this cytokine, released into the subarachnoid space can penetrate the DRG to activate STAT3. Previous results on increased bilateral IL-6 synthesis and the present manifestation of STAT3 activation in remote DRG following unilateral sciatic nerve injury may reflect a systemic reaction of the DRG neurons to nerve injury.
ER -
DUBOVÝ, Petr, Ivana HRADILOVÁ SVÍŽENSKÁ, Ilona KLUSÁKOVÁ, Viktória KOKOŠOVÁ, Václav BRÁZDA and Marek JOUKAL. Bilateral activation of STAT3 by phosphorylation at the tyrosine-705 (Y705) and serine-727 (S727) positions and its nuclear translocation in primary sensory neurons following unilateral sciatic nerve injury. \textit{Histochemistry and Cell Biology}. Heidelberg: Springer, 2018, vol.~150, No~1, p.~37-47. ISSN~0948-6143. Available from: https://dx.doi.org/10.1007/s00418-018-1656-y.
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