Prognostic role of c-Met in head and neck squamous cell cancer
tissues: a meta-analysis

J 2018

Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis

VŠIANSKÝ, Vít, Jaromír GUMULEC, Martina RAUDENSKÁ and Michal MASAŘÍK

Basic information

Original name

Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis

Authors

VŠIANSKÝ, Vít (203 Czech Republic, belonging to the institution), Jaromír GUMULEC (203 Czech Republic, guarantor, belonging to the institution), Martina RAUDENSKÁ (203 Czech Republic, belonging to the institution) and Michal MASAŘÍK (203 Czech Republic, belonging to the institution)

Edition

Scientific reports, LONDON, NATURE PUBLISHING GROUP, 2018, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.011

RIV identification code

RIV/00216224:14110/18:00106938

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/s41598-018-28672-8

UT WoS

000438024500002

Keywords in English

c-Met

Abstract

V originále

This meta-analysis aims to evaluate the effects of high c-Met levels in head and neck squamous cell carcinomas (HNSCC) on survival and clinicopathological features. Publications concerned with the clinical significance of c-Met protein expression in HNSCC were identified from the Scopus and Web of Science database searches. To elucidate the relationship between c-Met expression and clinical outcomes, a meta-analysis of the selected articles was conducted. Seventeen publications involving a total of 1724 patients met the inclusion criteria. c-Met overexpression was significantly correlated with poor overall survival (hazard ratio (HR) = 2.19, 95% confidence interval (CI) = 1.55-3.10). c-Met immunohistochemical staining positivity was also associated with worse relapse-free survival (HR = 1.64, 95% CI = 1.24-2.17) and presence of regional lymph node metastases (odds ratio (OR) = 1.76, 95% CI = 1.26-2.45). High levels of c-Met expression in HNSCC predict unfavorable prognosis associated with common clinicopathological features.

Links

NV16-29835A, research and development project

Name: Molekulárně-genetické markery predikce účinnosti radioterapie u nádorů hlavy a krku

ROZV/25/LF/2017, interní kód MU

Name: LF - Příspěvek na IP 2017

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects

Citovat

VŠIANSKÝ, Vít, Jaromír GUMULEC, Martina RAUDENSKÁ and Michal MASAŘÍK. Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2018, vol. 8, No 10370, p. 1-7. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-018-28672-8.

@article{1454676,
   author = {Všianský, Vít and Gumulec, Jaromír and Raudenská, Martina and Masařík, Michal},
   article_location = {LONDON},
   article_number = {10370},
   doi = {http://dx.doi.org/10.1038/s41598-018-28672-8},
   keywords = {c-Met},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific reports},
   title = {Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis},
   volume = {8},
   year = {2018}
}

TY  - JOUR
ID  - 1454676
AU  - Všianský, Vít - Gumulec, Jaromír - Raudenská, Martina - Masařík, Michal
PY  - 2018
TI  - Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis
JF  - Scientific reports
VL  - 8
IS  - 10370
SP  - 1-7
EP  - 1-7
PB  - NATURE PUBLISHING GROUP
SN  - 20452322
KW  - c-Met
N2  - This meta-analysis aims to evaluate the effects of high c-Met levels in head and neck squamous cell carcinomas (HNSCC) on survival and clinicopathological features. Publications concerned with the clinical significance of c-Met protein expression in HNSCC were identified from the Scopus and Web of Science database searches. To elucidate the relationship between c-Met expression and clinical outcomes, a meta-analysis of the selected articles was conducted. Seventeen publications involving a total of 1724 patients met the inclusion criteria. c-Met overexpression was significantly correlated with poor overall survival (hazard ratio (HR) = 2.19, 95% confidence interval (CI) = 1.55-3.10). c-Met immunohistochemical staining positivity was also associated with worse relapse-free survival (HR = 1.64, 95% CI = 1.24-2.17) and presence of regional lymph node metastases (odds ratio (OR) = 1.76, 95% CI = 1.26-2.45). High levels of c-Met expression in HNSCC predict unfavorable prognosis associated with common clinicopathological features.
ER  -

VŠIANSKÝ, Vít, Jaromír GUMULEC, Martina RAUDENSKÁ and Michal MASAŘÍK. Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis. \textit{Scientific reports}. LONDON: NATURE PUBLISHING GROUP, 2018, vol.~8, No~10370, p.~1-7. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-018-28672-8.

Detailed Information on Publication Record