VŠIANSKÝ, Vít, Jaromír GUMULEC, Martina RAUDENSKÁ and Michal MASAŘÍK. Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2018, vol. 8, No 10370, p. 1-7. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-018-28672-8.
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Basic information
Original name Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis
Authors VŠIANSKÝ, Vít (203 Czech Republic, belonging to the institution), Jaromír GUMULEC (203 Czech Republic, guarantor, belonging to the institution), Martina RAUDENSKÁ (203 Czech Republic, belonging to the institution) and Michal MASAŘÍK (203 Czech Republic, belonging to the institution).
Edition Scientific reports, LONDON, NATURE PUBLISHING GROUP, 2018, 2045-2322.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 4.011
RIV identification code RIV/00216224:14110/18:00106938
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1038/s41598-018-28672-8
UT WoS 000438024500002
Keywords in English c-Met
Tags 14110515, 14110518, rivok
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 10/2/2019 18:11.
Abstract
This meta-analysis aims to evaluate the effects of high c-Met levels in head and neck squamous cell carcinomas (HNSCC) on survival and clinicopathological features. Publications concerned with the clinical significance of c-Met protein expression in HNSCC were identified from the Scopus and Web of Science database searches. To elucidate the relationship between c-Met expression and clinical outcomes, a meta-analysis of the selected articles was conducted. Seventeen publications involving a total of 1724 patients met the inclusion criteria. c-Met overexpression was significantly correlated with poor overall survival (hazard ratio (HR) = 2.19, 95% confidence interval (CI) = 1.55-3.10). c-Met immunohistochemical staining positivity was also associated with worse relapse-free survival (HR = 1.64, 95% CI = 1.24-2.17) and presence of regional lymph node metastases (odds ratio (OR) = 1.76, 95% CI = 1.26-2.45). High levels of c-Met expression in HNSCC predict unfavorable prognosis associated with common clinicopathological features.
Links
NV16-29835A, research and development projectName: Molekulárně-genetické markery predikce účinnosti radioterapie u nádorů hlavy a krku
ROZV/25/LF/2017, interní kód MUName: LF - Příspěvek na IP 2017
Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects
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