PAZDERNIK, Michal, Zhi CHEN, Helena BEDÁŇOVÁ, Josef KAUTZNER, Vojtech MELENOVSKY, Vladimir KARMAZIN, Ivan MALEK, Ales TOMASEK, Eva OZÁBALOVÁ, Jan KREJČÍ, Janka FRANEKOVA, Andreas WAHLE, Honghai ZHANG, Tomas KOVARNIK and Milan SONKA. Early detection of cardiac allograft vasculopathy using highly automated 3-dimensional optical coherence tomography analysis. JOURNAL OF HEART AND LUNG TRANSPLANTATION. NEW YORK: ELSEVIER SCIENCE INC, 2018, vol. 37, No 8, p. 992-1000. ISSN 1053-2498. Available from: https://dx.doi.org/10.1016/j.healun.2018.04.002. |
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@article{1455016, author = {Pazdernik, Michal and Chen, Zhi and Bedáňová, Helena and Kautzner, Josef and Melenovsky, Vojtech and Karmazin, Vladimir and Malek, Ivan and Tomasek, Ales and Ozábalová, Eva and Krejčí, Jan and Franekova, Janka and Wahle, Andreas and Zhang, Honghai and Kovarnik, Tomas and Sonka, Milan}, article_location = {NEW YORK}, article_number = {8}, doi = {http://dx.doi.org/10.1016/j.healun.2018.04.002}, keywords = {cardiac allograft vasculopathy; OCT; intimal thickness; cholesterol; rapid progression}, language = {eng}, issn = {1053-2498}, journal = {JOURNAL OF HEART AND LUNG TRANSPLANTATION}, title = {Early detection of cardiac allograft vasculopathy using highly automated 3-dimensional optical coherence tomography analysis}, volume = {37}, year = {2018} }
TY - JOUR ID - 1455016 AU - Pazdernik, Michal - Chen, Zhi - Bedáňová, Helena - Kautzner, Josef - Melenovsky, Vojtech - Karmazin, Vladimir - Malek, Ivan - Tomasek, Ales - Ozábalová, Eva - Krejčí, Jan - Franekova, Janka - Wahle, Andreas - Zhang, Honghai - Kovarnik, Tomas - Sonka, Milan PY - 2018 TI - Early detection of cardiac allograft vasculopathy using highly automated 3-dimensional optical coherence tomography analysis JF - JOURNAL OF HEART AND LUNG TRANSPLANTATION VL - 37 IS - 8 SP - 992-1000 EP - 992-1000 PB - ELSEVIER SCIENCE INC SN - 10532498 KW - cardiac allograft vasculopathy KW - OCT KW - intimal thickness KW - cholesterol KW - rapid progression N2 - BACKGROUND: Optical coherence tomography (OCT) based studies of cardiac allograft vasculopathy (CAV) published thus far have focused mainly on frame-based qualitative analysis of the vascular wall. Full capabilities of this inherently 3-dimensional (3D) imaging modality to quantify CAV have not been fully exploited. METHODS: Coronary OCT imaging was performed at 1 month and 12 months after heart transplant (HTx) during routine surveillance cardiac catheterization. Both baseline and follow-up OCT examinations were analyzed using proprietary, highly automated 3D graph-based optimal segmentation software. Automatically identified borders were efficiently adjudicated using our "just-enough interaction" graph-based segmentation approach that allows to efficiently correct local and regional segmentation errors without slice-by-slice retracing of borders. RESULTS: A total of 50 patients with paired baseline and follow-up OCT studies were included. After registration of baseline and follow-up pullbacks, a total of 356 89 frames were analyzed per patient. During the first post-transplant year, significant reduction in the mean luminal area (p = 0.028) and progression in mean intimal thickness (p = 0.001) were observed. Proximal parts of imaged coronary arteries were affected more than distal parts (p < 0.001). High levels of LDL cholesterol (p = 0.02) and total cholesterol (p = 0.031) in the first month after HTx were the main factors associated with early CAV development. CONCLUSIONS: Our novel, highly automated 3D OCT image analysis method for analyzing intimal and medial thickness in HTx recipients provides fast, accurate, and highly detailed quantitative data on early CAV changes, which are characterized by significant luminal reduction and intimal thickness progression as early as within the first 12 months after HTx. (C) 2018 International Society for Heart and Lung Transplantation. All rights reserved. ER -
PAZDERNIK, Michal, Zhi CHEN, Helena BEDÁŇOVÁ, Josef KAUTZNER, Vojtech MELENOVSKY, Vladimir KARMAZIN, Ivan MALEK, Ales TOMASEK, Eva OZÁBALOVÁ, Jan KREJČÍ, Janka FRANEKOVA, Andreas WAHLE, Honghai ZHANG, Tomas KOVARNIK and Milan SONKA. Early detection of cardiac allograft vasculopathy using highly automated 3-dimensional optical coherence tomography analysis. \textit{JOURNAL OF HEART AND LUNG TRANSPLANTATION}. NEW YORK: ELSEVIER SCIENCE INC, 2018, vol.~37, No~8, p.~992-1000. ISSN~1053-2498. Available from: https://dx.doi.org/10.1016/j.healun.2018.04.002.
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