| RADOCHA, Jakub, Vladimír MAISNAR, Luděk POUR, Ivan ŠPIČKA, Jiří MINAŘÍK, Lenka SZELIGOVÁ, Petr PAVLÍČEK, Alexandra JUNGOVÁ, Marta KREJČÍ, Tomáš PIKA, Jan STRAUB, Lucie BROŽOVÁ, Lukáš STEJSKAL, Adriana HEINDORFER, Pavel JINDRA, Petr KESSLER, Peter MIKULA, Michal SYKORA, Marek WRÓBEL, Jiří JARKOVSKÝ and Roman HAJEK. Validation of multiple myeloma risk stratification indices in routine clinical practice: Analysis of data from the Czech Myeloma Group Registry of Monoclonal Gammopathies. Cancer Medicine. Houston: John Wiley & Sons Ltd., 2018, vol. 7, No 8, p. 4132-4145. ISSN 2045-7634. Available from: https://dx.doi.org/10.1002/cam4.1620. |
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@article{1455076,
author = {Radocha, Jakub and Maisnar, Vladimír and Pour, Luděk and Špička, Ivan and Minařík, Jiří and Szeligová, Lenka and Pavlíček, Petr and Jungová, Alexandra and Krejčí, Marta and Pika, Tomáš and Straub, Jan and Brožová, Lucie and Stejskal, Lukáš and Heindorfer, Adriana and Jindra, Pavel and Kessler, Petr and Mikula, Peter and Sykora, Michal and Wróbel, Marek and Jarkovský, Jiří and Hajek, Roman},
article_location = {Houston},
article_number = {8},
doi = {http://dx.doi.org/10.1002/cam4.1620},
keywords = {Czech Myeloma Group Registry; monoclonal gammopathies; multiple myeloma; overall survival; real-world; risk stratification},
language = {eng},
issn = {2045-7634},
journal = {Cancer Medicine},
title = {Validation of multiple myeloma risk stratification indices in routine clinical practice: Analysis of data from the Czech Myeloma Group Registry of Monoclonal Gammopathies},
volume = {7},
year = {2018}
}
TY - JOUR
ID - 1455076
AU - Radocha, Jakub - Maisnar, Vladimír - Pour, Luděk - Špička, Ivan - Minařík, Jiří - Szeligová, Lenka - Pavlíček, Petr - Jungová, Alexandra - Krejčí, Marta - Pika, Tomáš - Straub, Jan - Brožová, Lucie - Stejskal, Lukáš - Heindorfer, Adriana - Jindra, Pavel - Kessler, Petr - Mikula, Peter - Sykora, Michal - Wróbel, Marek - Jarkovský, Jiří - Hajek, Roman
PY - 2018
TI - Validation of multiple myeloma risk stratification indices in routine clinical practice: Analysis of data from the Czech Myeloma Group Registry of Monoclonal Gammopathies
JF - Cancer Medicine
VL - 7
IS - 8
SP - 4132-4145
EP - 4132-4145
PB - John Wiley & Sons Ltd.
SN - 20457634
KW - Czech Myeloma Group Registry
KW - monoclonal gammopathies
KW - multiple myeloma
KW - overall survival
KW - real-world
KW - risk stratification
N2 - This study used data from the Czech Myeloma Group Registry of Monoclonal Gammopathies to validate the International Myeloma Working Group (IMWG) and revised International Staging System (R-ISS) indices for risk stratification in patients with multiple myeloma (MM) in clinical practice. Patients were included if they had symptomatic MM, complete data allowing R-ISS and IMWG staging (including cytogenetic information regarding t(4;14), t(14;16), and del(17p)), and key parameters for treatment evaluation. Median overall survival (OS) in included patients (n = 550) was 47.7 (95% CI: 39.5-55.9) and 46.2 (95% CI: 38.9-53.5) months from diagnosis and initiation of first-line therapy, respectively. Patients categorized as higher vs lower risk had reduced survival; median OS from diagnosis was 35.4 (95% CI: 30.5-40.3) vs 58.3 (95% CI: 53.8-62.9) months in high-risk vs other patients (IMWG; P = .001) and 34.1 (95% CI: 30.2-38.0) vs 47.2 (95% CI: 43.4-51.0) months in Stage III vs Stage II patients (R-ISS; P < .001). In conclusion, IMWG and R-ISS risk stratification indices are applicable to patients with MM in a real-world setting.
ER -
RADOCHA, Jakub, Vladimír MAISNAR, Luděk POUR, Ivan ŠPIČKA, Jiří MINAŘÍK, Lenka SZELIGOVÁ, Petr PAVLÍČEK, Alexandra JUNGOVÁ, Marta KREJČÍ, Tomáš PIKA, Jan STRAUB, Lucie BROŽOVÁ, Lukáš STEJSKAL, Adriana HEINDORFER, Pavel JINDRA, Petr KESSLER, Peter MIKULA, Michal SYKORA, Marek WRÓBEL, Jiří JARKOVSKÝ and Roman HAJEK. Validation of multiple myeloma risk stratification indices in routine clinical practice: Analysis of data from the Czech Myeloma Group Registry of Monoclonal Gammopathies. \textit{Cancer Medicine}. Houston: John Wiley \&{} Sons Ltd., 2018, vol.~7, No~8, p.~4132-4145. ISSN~2045-7634. Available from: https://dx.doi.org/10.1002/cam4.1620.
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