J 2018

Cardiac resynchronization therapy - A comparison of VV delay optimization by 3D echocardiography using systolic dyssynchrony index and QRS width assessment at 6 months after CRT implantation

VONDRAK, Jiri, Dan MAREK, Jan VECERA, Klára BENEŠOVÁ, Petr VOJTISEK et. al.

Basic information

Original name

Cardiac resynchronization therapy - A comparison of VV delay optimization by 3D echocardiography using systolic dyssynchrony index and QRS width assessment at 6 months after CRT implantation

Authors

VONDRAK, Jiri (203 Czech Republic, guarantor), Dan MAREK (203 Czech Republic), Jan VECERA (203 Czech Republic), Klára BENEŠOVÁ (203 Czech Republic, belonging to the institution) and Petr VOJTISEK (203 Czech Republic)

Edition

cor et Vasa, AMSTERDAM, ELSEVIER SCIENCE BV, 2018, 0010-8650

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/18:00104186

Organization unit

Faculty of Medicine

DOI

UT WoS

000442902500005

Keywords in English

3D echocardiography; Dyssynchrony; Cardiac resynchronization therapy; Optimization; Systolic dyssynchrony index; Clinical outcome; Volumetric responders

Tags

Tags

International impact, Reviewed
Změněno: 9/2/2019 21:15, Soňa Böhmová

Abstract

V originále

Aim: The aim of this study was to compare the setting of interventricular (VV) delay by 3D echocardiography (3DE) using systolic dyssynchrony index (SDI) versus QRS width measurement in new cardiac resynchronization therapy (CRT) recipients. We observed the impact on the reduction of left ventricle volumes and increase in volumetric responders (defined as a = 15% reduction in left ventricular end-systolic volume (LVESv)) at the 6-month follow-up. Methods: We included 63 patients with recently implanted CRT in this open-label, randomized trial. Patients were randomized into two groups. VV delay was set by the QRS width in the group 1 (n 31) to obtain the narrowest QRS complex and by SDI in the group 2 (n 32) to achieve the lowest possible value. We evaluated LVESv, left ventricular ejection fraction (LVEF) by 3DE, before CRT implantation and at 6-month follow-up, in all patients. We also obtained clinical parameters and the level of NT-proBNP. Results: The second group showed only a trend toward greater reduction of LVESv (-33 +/- 55 ml vs. -48 +/- 43 ml; P 0.367), increase in LVEF (+ 7.3 +/- 10.9% vs. + 10.2 +/- 9.4%; P 0.210) and greater number of volumetric responders (14 vs. 18; P 0.612) compared with the group 1 at 6-month follow-up. There were also no significant differences in clinical outcomes and the level of NT-proBNP. Conclusion: Individual CRT optimization using SDI compared with QRS duration assessment did not reveal any significant differences in echocardiographic parameters and clinical outcomes at 6-month follow-up. (c) 2017 The Czech Society of Cardiology. Published by Elsevier Sp. z o. o. All rights reserved.