VONDRAK, Jiri, Dan MAREK, Jan VECERA, Klára BENEŠOVÁ and Petr VOJTISEK. Cardiac resynchronization therapy - A comparison of VV delay optimization by 3D echocardiography using systolic dyssynchrony index and QRS width assessment at 6 months after CRT implantation. cor et Vasa. AMSTERDAM: ELSEVIER SCIENCE BV, 2018, vol. 60, No 4, p. "E367"-"E376", 10 pp. ISSN 0010-8650. Available from: https://dx.doi.org/10.1016/j.crvasa.2017.11.006.
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Basic information
Original name Cardiac resynchronization therapy - A comparison of VV delay optimization by 3D echocardiography using systolic dyssynchrony index and QRS width assessment at 6 months after CRT implantation
Authors VONDRAK, Jiri (203 Czech Republic, guarantor), Dan MAREK (203 Czech Republic), Jan VECERA (203 Czech Republic), Klára BENEŠOVÁ (203 Czech Republic, belonging to the institution) and Petr VOJTISEK (203 Czech Republic).
Edition cor et Vasa, AMSTERDAM, ELSEVIER SCIENCE BV, 2018, 0010-8650.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/18:00104186
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.crvasa.2017.11.006
UT WoS 000442902500005
Keywords in English 3D echocardiography; Dyssynchrony; Cardiac resynchronization therapy; Optimization; Systolic dyssynchrony index; Clinical outcome; Volumetric responders
Tags 14119612, rivok
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 9/2/2019 21:15.
Abstract
Aim: The aim of this study was to compare the setting of interventricular (VV) delay by 3D echocardiography (3DE) using systolic dyssynchrony index (SDI) versus QRS width measurement in new cardiac resynchronization therapy (CRT) recipients. We observed the impact on the reduction of left ventricle volumes and increase in volumetric responders (defined as a = 15% reduction in left ventricular end-systolic volume (LVESv)) at the 6-month follow-up. Methods: We included 63 patients with recently implanted CRT in this open-label, randomized trial. Patients were randomized into two groups. VV delay was set by the QRS width in the group 1 (n 31) to obtain the narrowest QRS complex and by SDI in the group 2 (n 32) to achieve the lowest possible value. We evaluated LVESv, left ventricular ejection fraction (LVEF) by 3DE, before CRT implantation and at 6-month follow-up, in all patients. We also obtained clinical parameters and the level of NT-proBNP. Results: The second group showed only a trend toward greater reduction of LVESv (-33 +/- 55 ml vs. -48 +/- 43 ml; P 0.367), increase in LVEF (+ 7.3 +/- 10.9% vs. + 10.2 +/- 9.4%; P 0.210) and greater number of volumetric responders (14 vs. 18; P 0.612) compared with the group 1 at 6-month follow-up. There were also no significant differences in clinical outcomes and the level of NT-proBNP. Conclusion: Individual CRT optimization using SDI compared with QRS duration assessment did not reveal any significant differences in echocardiographic parameters and clinical outcomes at 6-month follow-up. (c) 2017 The Czech Society of Cardiology. Published by Elsevier Sp. z o. o. All rights reserved.
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