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@article{1455196,
author = {Kiechl, Stefan and Pechlaner, Raimund and Willeit, Peter and Notdurfter, Marlene and Paulweber, Bernhard and Willeit, Karin and Werner, Philipp and Ruckenstuhl, Christoph and Iglseder, Bernhard and Weger, Siegfried and Mairhofer, Barbara and Gartner, Markus and Kedenko, Ludmilla and Chmelíková, Monika and Stekovic, Slaven and Stuppner, Hermann and Oberhollenzer, Friedrich and Kroemer, Guido and Mayr, Manuel and Eisenberg, Tobias and Tilg, Herbert and Madeo, Frank and Willeit, Johann},
article_location = {Bethesda},
article_number = {2},
doi = {http://dx.doi.org/10.1093/ajcn/nqy102},
keywords = {polyamines; spermidine; life span; cancer; vascular disease},
language = {eng},
issn = {0002-9165},
journal = {American Journal of Clinical Nutrition},
title = {Higher spermidine intake is linked to lower mortality: a prospective population-based study},
volume = {108},
year = {2018}
}
TY - JOUR
ID - 1455196
AU - Kiechl, Stefan - Pechlaner, Raimund - Willeit, Peter - Notdurfter, Marlene - Paulweber, Bernhard - Willeit, Karin - Werner, Philipp - Ruckenstuhl, Christoph - Iglseder, Bernhard - Weger, Siegfried - Mairhofer, Barbara - Gartner, Markus - Kedenko, Ludmilla - Chmelíková, Monika - Stekovic, Slaven - Stuppner, Hermann - Oberhollenzer, Friedrich - Kroemer, Guido - Mayr, Manuel - Eisenberg, Tobias - Tilg, Herbert - Madeo, Frank - Willeit, Johann
PY - 2018
TI - Higher spermidine intake is linked to lower mortality: a prospective population-based study
JF - American Journal of Clinical Nutrition
VL - 108
IS - 2
SP - 371-380
EP - 371-380
PB - American Society for Nutrition
SN - 00029165
KW - polyamines
KW - spermidine
KW - life span
KW - cancer
KW - vascular disease
N2 - Background: Spermidine administration is linked to increased survival in several animal models. Objective: The aim of this study was to test the potential association between spermidine content in diet and mortality in humans. Design: This prospective community-based cohort study included 829 participants aged 45-84 y, 49.9% of whom were male. Diet was assessed by repeated dietitian-administered validated food-frequency questionnaires (2540 assessments) in 1995, 2000, 2005, and 2010. During follow-up between 1995 and 2015, 341 deaths occurred. Results: All-cause mortality (deaths per 1000 person-years) decreased across thirds of increasing spermidine intake from 40.5 (95% CI: 36.1, 44.7) to 23.7 (95% CI: 20.0, 27.0) and 15.1 (95% CI: 12.6, 17.8), corresponding to an age-, sex-and caloric intake-adjusted 20-y cumulative mortality incidence of 0.48 (95% CI: 0.45, 0.51), 0.41 (95% CI: 0.38, 0.45), and 0.38 (95% CI: 0.34, 0.41), respectively. The age-, sex-and caloric ratio-adjusted HR for all-cause death per 1-SD higher spermidine intake was 0.74 (95% CI: 0.66, 0.83; P < 0.001). Further adjustment for lifestyle factors, established predictors of mortality, and other dietary features yielded an HR of 0.76 (95% CI: 0.67, 0.86; P < 0.001). The association was consistent in subgroups, robust against unmeasured confounding, and independently validated in the Salzburg Atherosclerosis Prevention Program in Subjects at High Individual Risk (SAPHIR) Study (age-, sex-, and caloric ratioadjusted HR per 1-SD higher spermidine intake: 0.71; 95% CI: 0.53, 0.95; P = 0.019). The difference in mortality risk between the top and bottom third of spermidine intakes was similar to that associated with a 5.7-y (95% CI: 3.6, 8.1 y) younger age. Conclusion: Our findings lend epidemiologic support to the concept that nutrition rich in spermidine is linked to increased survival in humans.
ER -
KIECHL, Stefan, Raimund PECHLANER, Peter WILLEIT, Marlene NOTDURFTER, Bernhard PAULWEBER, Karin WILLEIT, Philipp WERNER, Christoph RUCKENSTUHL, Bernhard IGLSEDER, Siegfried WEGER, Barbara MAIRHOFER, Markus GARTNER, Ludmilla KEDENKO, Monika CHMELÍKOVÁ, Slaven STEKOVIC, Hermann STUPPNER, Friedrich OBERHOLLENZER, Guido KROEMER, Manuel MAYR, Tobias EISENBERG, Herbert TILG, Frank MADEO and Johann WILLEIT. Higher spermidine intake is linked to lower mortality: a prospective population-based study. \textit{American Journal of Clinical Nutrition}. Bethesda: American Society for Nutrition, 2018, vol.~108, No~2, p.~371-380. ISSN~0002-9165. Available from: https://dx.doi.org/10.1093/ajcn/nqy102.
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