J 2018

Association of interleukin 6, interleukin 7 receptor alpha, and interleukin 12B gene polymorphisms with multiple sclerosis

BENEŠOVÁ, Yvonne, Anna VAŠKŮ and Julie BIENERTOVÁ VAŠKŮ

Basic information

Original name

Association of interleukin 6, interleukin 7 receptor alpha, and interleukin 12B gene polymorphisms with multiple sclerosis

Authors

BENEŠOVÁ, Yvonne (203 Czech Republic, guarantor, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, belonging to the institution) and Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution)

Edition

Acta Neurologica Belgica, Heidelberg, Springer Heidelberg, 2018, 0300-9009

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.612

RIV identification code

RIV/00216224:14110/18:00104199

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s13760-018-0994-9

UT WoS

000442249600020

Keywords in English

Gene; Interleukin 6; Interleukin 7 receptor alpha chain; Interleukin 12B; Multiple sclerosis; Single nucleotide polymorphism

Tags

14110221, 14110518, rivok

Tags

International impact, Reviewed
Změněno: 9/2/2019 20:48, Soňa Böhmová

Abstract

V originále

Pro-inflammatory and anti-inflammatory cytokines have been shown to play a crucial role in the pathophysiology of multiple sclerosis (MS). We investigated the association between interleukin (IL) IL6-174 G/C (rs1800795), IL7RA C/T (rs6897932), and IL-12B A1188C (rs3212227) gene polymorphisms (SNPs) and MS. The study consisted of 297 unrelated MS patients and 135 healthy individuals. In IL6-174G/C (rs1800795), a significant association between the C allele and MS risk [OR 1.41, 95% CI (1.05-1.92); P = 0.025] was found. Carriage of genotypes CC and CG were more common in MS patients [OR 1.58, 95% CI (1.04-2.39); P = 0.031] and also in female MS patients [OR 1.68, 95% CI (1.02-2.79); P = 0.043]. However, after applying Bonferroni's correction the differences did not remain significant. No significant association between the IL7RA C/T (rs6897932) and IL12B A1188C (rs3212227) gene polymorphisms and MS susceptibility was observed. Regarding IL-12B A1188C (rs3212227), a significant association between the CC genotype and MS progression, expressed as MSSS, was demonstrated in the female MS group. Our results indicate that the distribution of IL6-174G/C (rs1800795) SNP was marginally associated with MS susceptibility. We also showed that IL-12B A1188C (rs3212227) can contribute to the progression of the disease in the Czech population.

Links

MUNI/A/1426/2015, interní kód MU
Name: Genetická a epigenetická patofyziologie vybraných stavů (Acronym: Genetika a epigenetika)
Investor: Masaryk University, Category A
Displayed: 10/11/2024 08:41