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@article{1455316,
author = {Benešová, Yvonne and Vašků, Anna and Bienertová Vašků, Julie},
article_location = {Heidelberg},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s13760-018-0994-9},
keywords = {Gene; Interleukin 6; Interleukin 7 receptor alpha chain; Interleukin 12B; Multiple sclerosis; Single nucleotide polymorphism},
language = {eng},
issn = {0300-9009},
journal = {Acta Neurologica Belgica},
title = {Association of interleukin 6, interleukin 7 receptor alpha, and interleukin 12B gene polymorphisms with multiple sclerosis},
volume = {118},
year = {2018}
}
TY - JOUR
ID - 1455316
AU - Benešová, Yvonne - Vašků, Anna - Bienertová Vašků, Julie
PY - 2018
TI - Association of interleukin 6, interleukin 7 receptor alpha, and interleukin 12B gene polymorphisms with multiple sclerosis
JF - Acta Neurologica Belgica
VL - 118
IS - 3
SP - 493-501
EP - 493-501
PB - Springer Heidelberg
SN - 03009009
KW - Gene
KW - Interleukin 6
KW - Interleukin 7 receptor alpha chain
KW - Interleukin 12B
KW - Multiple sclerosis
KW - Single nucleotide polymorphism
N2 - Pro-inflammatory and anti-inflammatory cytokines have been shown to play a crucial role in the pathophysiology of multiple sclerosis (MS). We investigated the association between interleukin (IL) IL6-174 G/C (rs1800795), IL7RA C/T (rs6897932), and IL-12B A1188C (rs3212227) gene polymorphisms (SNPs) and MS. The study consisted of 297 unrelated MS patients and 135 healthy individuals. In IL6-174G/C (rs1800795), a significant association between the C allele and MS risk [OR 1.41, 95% CI (1.05-1.92); P = 0.025] was found. Carriage of genotypes CC and CG were more common in MS patients [OR 1.58, 95% CI (1.04-2.39); P = 0.031] and also in female MS patients [OR 1.68, 95% CI (1.02-2.79); P = 0.043]. However, after applying Bonferroni's correction the differences did not remain significant. No significant association between the IL7RA C/T (rs6897932) and IL12B A1188C (rs3212227) gene polymorphisms and MS susceptibility was observed. Regarding IL-12B A1188C (rs3212227), a significant association between the CC genotype and MS progression, expressed as MSSS, was demonstrated in the female MS group. Our results indicate that the distribution of IL6-174G/C (rs1800795) SNP was marginally associated with MS susceptibility. We also showed that IL-12B A1188C (rs3212227) can contribute to the progression of the disease in the Czech population.
ER -
BENEŠOVÁ, Yvonne, Anna VAŠKŮ and Julie BIENERTOVÁ VAŠKŮ. Association of interleukin 6, interleukin 7 receptor alpha, and interleukin 12B gene polymorphisms with multiple sclerosis. \textit{Acta Neurologica Belgica}. Heidelberg: Springer Heidelberg, 2018, vol.~118, No~3, p.~493-501. ISSN~0300-9009. Available from: https://dx.doi.org/10.1007/s13760-018-0994-9.
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