Host-dependent variables: The missing link to personalized
medicine

J 2018

Host-dependent variables: The missing link to personalized medicine

DEMLOVÁ, Regina, Lenka ZDRAŽILOVÁ DUBSKÁ, Jaroslav ŠTĚRBA, Giorgio STANTA, Dalibor VALÍK et. al.

Basic information

Original name

Host-dependent variables: The missing link to personalized medicine

Authors

DEMLOVÁ, Regina (203 Czech Republic, belonging to the institution), Lenka ZDRAŽILOVÁ DUBSKÁ (203 Czech Republic, belonging to the institution), Jaroslav ŠTĚRBA (203 Czech Republic, belonging to the institution), Giorgio STANTA (380 Italy) and Dalibor VALÍK (203 Czech Republic, guarantor, belonging to the institution)

Edition

EJSO, OXFORD, ELSEVIER SCI LTD, 2018, 0748-7983

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.379

RIV identification code

RIV/00216224:14110/18:00104207

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.ejso.2018.04.014

UT WoS

000444356500002

Keywords in English

Cancer; Personalized medicine; Tumour microenvironment; Immunobiology; Targeted therapy; Pharmacogenetics

Abstract

V originále

Individualized medicine has the potential to tailor anticancer therapy with the best response and highest safety margin to provide better patient care. However, modern targeted therapies are still being tested through clinical trials comparing preselected patient cohorts and assessed upon behaviour of group averages. Clinically manifesting malignant disease requires identification of host - and tumour-dependent variables such as biological characteristics of the tumour and its microenvironment including immune response features, and overall capacity of the host to receive, tolerate and efficiently utilize treatment. Contemporary medical oncology including clinical trial design need to refocus from assessing group averages to individuality taking into consideration time dependent host-associated characteristics and reinventing outliers to be appreciated as naturally occurring variables collectively determining the ultimate outcome of malignant disease. (C) 2018 Published by Elsevier Ltd.

Links

LM2015090, research and development project

Name: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Acronym: CZECRIN)

Investor: Ministry of Education, Youth and Sports of the CR

NV16-33209A, research and development project

Name: Sekvenování nové generace a expresní profilování jako diagnostický podklad pro návrhy individualizovaných léčebných plánů pro děti se solidními nádory

NV16-34083A, research and development project

Name: Receptorové tyrozinkinázy a navazující signální dráhy jako potenciální cíle léčby refrakterních solidních nádorů dětského věku

90089, large research infrastructures

Name: BBMRI-CZ II

Citovat

DEMLOVÁ, Regina, Lenka ZDRAŽILOVÁ DUBSKÁ, Jaroslav ŠTĚRBA, Giorgio STANTA and Dalibor VALÍK. Host-dependent variables: The missing link to personalized medicine. EJSO. OXFORD: ELSEVIER SCI LTD, 2018, vol. 44, No 9, p. 1289-1294. ISSN 0748-7983. Available from: https://dx.doi.org/10.1016/j.ejso.2018.04.014.

@article{1455696,
   author = {Demlová, Regina and Zdražilová Dubská, Lenka and Štěrba, Jaroslav and Stanta, Giorgio and Valík, Dalibor},
   article_location = {OXFORD},
   article_number = {9},
   doi = {http://dx.doi.org/10.1016/j.ejso.2018.04.014},
   keywords = {Cancer; Personalized medicine; Tumour microenvironment; Immunobiology; Targeted therapy; Pharmacogenetics},
   language = {eng},
   issn = {0748-7983},
   journal = {EJSO},
   title = {Host-dependent variables: The missing link to personalized medicine},
   url = {https://www.sciencedirect.com/science/article/pii/S0748798318310205?via%3Dihub},
   volume = {44},
   year = {2018}
}

TY  - JOUR
ID  - 1455696
AU  - Demlová, Regina - Zdražilová Dubská, Lenka - Štěrba, Jaroslav - Stanta, Giorgio - Valík, Dalibor
PY  - 2018
TI  - Host-dependent variables: The missing link to personalized medicine
JF  - EJSO
VL  - 44
IS  - 9
SP  - 1289-1294
EP  - 1289-1294
PB  - ELSEVIER SCI LTD
SN  - 07487983
KW  - Cancer
KW  - Personalized medicine
KW  - Tumour microenvironment
KW  - Immunobiology
KW  - Targeted therapy
KW  - Pharmacogenetics
UR  - https://www.sciencedirect.com/science/article/pii/S0748798318310205?via%3Dihub
N2  - Individualized medicine has the potential to tailor anticancer therapy with the best response and highest safety margin to provide better patient care. However, modern targeted therapies are still being tested through clinical trials comparing preselected patient cohorts and assessed upon behaviour of group averages. Clinically manifesting malignant disease requires identification of host - and tumour-dependent variables such as biological characteristics of the tumour and its microenvironment including immune response features, and overall capacity of the host to receive, tolerate and efficiently utilize treatment. Contemporary medical oncology including clinical trial design need to refocus from assessing group averages to individuality taking into consideration time dependent host-associated characteristics and reinventing outliers to be appreciated as naturally occurring variables collectively determining the ultimate outcome of malignant disease. (C) 2018 Published by Elsevier Ltd.
ER  -

DEMLOVÁ, Regina, Lenka ZDRAŽILOVÁ DUBSKÁ, Jaroslav ŠTĚRBA, Giorgio STANTA and Dalibor VALÍK. Host-dependent variables: The missing link to personalized medicine. \textit{EJSO}. OXFORD: ELSEVIER SCI LTD, 2018, vol.~44, No~9, p.~1289-1294. ISSN~0748-7983. Available from: https://dx.doi.org/10.1016/j.ejso.2018.04.014.

Detailed Information on Publication Record