| DEMLOVÁ, Regina, Lenka ZDRAŽILOVÁ DUBSKÁ, Jaroslav ŠTĚRBA, Giorgio STANTA and Dalibor VALÍK. Host-dependent variables: The missing link to personalized medicine. EJSO. OXFORD: ELSEVIER SCI LTD, 2018, vol. 44, No 9, p. 1289-1294. ISSN 0748-7983. Available from: https://dx.doi.org/10.1016/j.ejso.2018.04.014. |
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@article{1455696,
author = {Demlová, Regina and Zdražilová Dubská, Lenka and Štěrba, Jaroslav and Stanta, Giorgio and Valík, Dalibor},
article_location = {OXFORD},
article_number = {9},
doi = {http://dx.doi.org/10.1016/j.ejso.2018.04.014},
keywords = {Cancer; Personalized medicine; Tumour microenvironment; Immunobiology; Targeted therapy; Pharmacogenetics},
language = {eng},
issn = {0748-7983},
journal = {EJSO},
title = {Host-dependent variables: The missing link to personalized medicine},
url = {https://www.sciencedirect.com/science/article/pii/S0748798318310205?via%3Dihub},
volume = {44},
year = {2018}
}
TY - JOUR
ID - 1455696
AU - Demlová, Regina - Zdražilová Dubská, Lenka - Štěrba, Jaroslav - Stanta, Giorgio - Valík, Dalibor
PY - 2018
TI - Host-dependent variables: The missing link to personalized medicine
JF - EJSO
VL - 44
IS - 9
SP - 1289-1294
EP - 1289-1294
PB - ELSEVIER SCI LTD
SN - 07487983
KW - Cancer
KW - Personalized medicine
KW - Tumour microenvironment
KW - Immunobiology
KW - Targeted therapy
KW - Pharmacogenetics
UR - https://www.sciencedirect.com/science/article/pii/S0748798318310205?via%3Dihub
N2 - Individualized medicine has the potential to tailor anticancer therapy with the best response and highest safety margin to provide better patient care. However, modern targeted therapies are still being tested through clinical trials comparing preselected patient cohorts and assessed upon behaviour of group averages. Clinically manifesting malignant disease requires identification of host - and tumour-dependent variables such as biological characteristics of the tumour and its microenvironment including immune response features, and overall capacity of the host to receive, tolerate and efficiently utilize treatment. Contemporary medical oncology including clinical trial design need to refocus from assessing group averages to individuality taking into consideration time dependent host-associated characteristics and reinventing outliers to be appreciated as naturally occurring variables collectively determining the ultimate outcome of malignant disease. (C) 2018 Published by Elsevier Ltd.
ER -
DEMLOVÁ, Regina, Lenka ZDRAŽILOVÁ DUBSKÁ, Jaroslav ŠTĚRBA, Giorgio STANTA and Dalibor VALÍK. Host-dependent variables: The missing link to personalized medicine. \textit{EJSO}. OXFORD: ELSEVIER SCI LTD, 2018, vol.~44, No~9, p.~1289-1294. ISSN~0748-7983. Available from: https://dx.doi.org/10.1016/j.ejso.2018.04.014.
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